Skip to main content
Ir a la página de inicio de la Comisión Europea (se abrirá en una nueva ventana)
español es
CORDIS - Resultados de investigaciones de la UE
CORDIS
Contenido archivado el 2024-04-16

PET investigation of cellular regeneration and degeneration

Objetivo

To foster collaboration between groups, evaluate the capacity of the tools, broadcast informations and encourage common protocols in the use of positron emission tomography (PET).
Nearly 30 European centres using positron emission tomography (PET) participated in a collaborative programme which was both methodological and clinical. Instrumentation and radiochemistry intercomparison of techniques, standardizations and protocols led to general agreements allowing comparable results to be obtained. This is particularly important since in the future various centres will work with common clinical protocols. The modelling approach has led also to interesting results in comparing the various methods of measuring cerebral and myocardial blood flow and in studying the effect of tissue heterogeneity on the accuracy of biological parameters estimation.

In neurology and cardiology multicentre studies of fluoro-2-deoxy-D-glucose (FDG) metabolism in Alzheimer's disease and of myocardial viability in coronary artery disease were established. The preliminary results obtained demonstrate that a large scale programme at the European level is possible. In psychiatry after an estimation of the European potential, promising research areas were identified in psychopharmacology and brain metabolism. In oncology, which is a field of choice for the emergence of diagnostic tests the efforts were focused on the search for proliferation indicators and on sugar or amino acid metabolism as an estimation of tumour grade severity and response to treatment.
PET is an imaging technique which permits regional in vivo accurate measurement of radiotracers labelled with positrons emitting radioisotopes. Such measurements are required for the quantification of physiological, metabolic or pharmacological parameters in human in normal or pathological situations.

According to the main pathologies which occur in the developed countries (neurological, psychiatric, cardiovascular diseases and cancer) for which no methods except PET allows a non traumatic estimation of cell degeneration (effect of ischemic disorders on progressive degeneration of nerve and cardiac cells, dementia, epilepsy, heart and brain infarction), or cell regeneration (after nerve cell graft, heart transplant) and abnormal cell proliferation (in oncology), it was thought that a concerted programme would have a high impact on the understanding of the outset of these processes and may help to follow their treatment.

In this project a special attention would be paid to the pharmacological approaches since PET also allows pharmacokinetics studies, estimation of interaction of drugs with their specific receptors and as a consequence an improvement in drug design and administration.

However the quality of the results to be expected would be very dependent on the quality of the methodology used by the different participating teams, therefore in addition to the coordination in clinical sciences (neurology, psychiatry, cardiology and oncology) a strong cooperation should take place in instrumentation, radiochemistry and modelling.

Ámbito científico (EuroSciVoc)

CORDIS clasifica los proyectos con EuroSciVoc, una taxonomía plurilingüe de ámbitos científicos, mediante un proceso semiautomático basado en técnicas de procesamiento del lenguaje natural. Véas: El vocabulario científico europeo..

Para utilizar esta función, debe iniciar sesión o registrarse

Programa(s)

Programas de financiación plurianuales que definen las prioridades de la UE en materia de investigación e innovación.

Tema(s)

Las convocatorias de propuestas se dividen en temas. Un tema define una materia o área específica para la que los solicitantes pueden presentar propuestas. La descripción de un tema comprende su alcance específico y la repercusión prevista del proyecto financiado.

Datos no disponibles

Convocatoria de propuestas

Procedimiento para invitar a los solicitantes a presentar propuestas de proyectos con el objetivo de obtener financiación de la UE.

Datos no disponibles

Régimen de financiación

Régimen de financiación (o «Tipo de acción») dentro de un programa con características comunes. Especifica: el alcance de lo que se financia; el porcentaje de reembolso; los criterios específicos de evaluación para optar a la financiación; y el uso de formas simplificadas de costes como los importes a tanto alzado.

CON - Coordination of research actions

Coordinador

Universite de Liege
Aportación de la UE
Sin datos
Dirección
Sart Tilman, Bat. B30
4000 Liege
Bélgica

Ver en el mapa

Coste total

Los costes totales en que ha incurrido esta organización para participar en el proyecto, incluidos los costes directos e indirectos. Este importe es un subconjunto del presupuesto total del proyecto.

Sin datos
Mi folleto 0 0