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Candidate drug carrier systems containing the chemotherapeutic agent Mitomycin C have been prepared for the treatment of colorectal carcinoma. The research has encompassed tumour targeting using synthetic polymers, microspheres, emulsions and liposomes.
Sufficient supplies of Mitomycin C were obtained. The various animal models and cell models that are required for the in vivo and in vitro assessment of the novel delivery systems were established and were available to the participants of the concerted action.
Microspheres using different encapsulating agents (ethycellulose, polylactide coglycolide) and loaded with Mitomycin C have been prepared. Experiments have been conducted in patients where drug loaded microspheres have been injected intraarterial for the treatment of metastic disease in the liver. The microspheres gave a greatly reduced drug concentration in the systemic circulation.
A carbamate pro drug of Mitomycin C, for incorporation into lipid carriers (liposomes and emulsion) has been prepared. This is now being evaluated in cell culture systems and metastases' models. A liposomal delivery system has been formulated and was tested in animal models. Polymeric conjugates of Mitomycin C were also being prepared.
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