Objective
Chronic inflammatory diseases of the intestine impose significant healthcare, social and economic problems throughout Europe. A multifactorial aetiology with environmental, immulogical and genetic components is suggested. The proposal will use three mouse models of intestinal inflammation to examine the interactions between the intestinal bacterial micro flora and the mucosal immune system. The effects of individual bacterial species and their defined antigens on induction and regulation of pathogenesis will be investigated in selectively re- colonised germfree systems. The role of the intestinal epithelium and associated extra cellular matrix components will be explored. New model systems to analyse the involvement of specific gene transcription factors in the initiation and control of mucosal inflammation will be produced.
1 Produce germfree IL-10 and Galphai2 KO mice, 100% for Galphai2 KO, IL-10 KO not pursued;
2 Produce germfree b-LACK beta-TCR mice, strategy changed;
3 Isolate and culture commensal and pathogenic gut bacteria, 100%;
4 Produce transcription factor-modified cells and chimeric mice, 50%;
5 Colonise germfree mice, 100%;
6 Define effect of bacterial colonisation on colitis pathogenesis, 100%;
7 Production of bacteria-reactive T cell lines and clones, 100%;
8 Generate b-LACK-reactive T cell lines and clones, 100%;
9 Determine effect of microflora bacteria on induction of regulatory T cells, 90%;
10 Fully characterise effect of bacteria on colitis immunopathology, 100%;
11 Analyse contribution of epithelium to induction and regulation of colitis, 100%;
12 Produce genetic induction models of colitis, 80%.
Fields of science (EuroSciVoc)
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
- natural sciences biological sciences microbiology bacteriology
- medical and health sciences health sciences inflammatory diseases
- medical and health sciences clinical medicine gastroenterology inflammatory bowel disease
- medical and health sciences basic medicine immunology
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Programme(s)
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Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Topic(s)
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Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
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Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
Funding Scheme
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Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Coordinator
BS8 1TH BRISTOL, CLIFTON
United Kingdom
The total costs incurred by this organisation to participate in the project, including direct and indirect costs. This amount is a subset of the overall project budget.