Objective
HFE molecules have a pivotal role in controlling iron metabolism, as best exemplified by classical hereditary hemochromatosis, the most common hereditary disorder in European populations. Tools have been and will be developed (i.e. HFE specific monoclonal antibodies, KO and HFE transgenic mice) in the clustered laboratories to define HFE expression and mode of action in normal tissues and malignant cells, in cell activation, in virus-infected cells (specially with chronic viruses such as hepatitis), and in various iron-overload related pathologies. Complementary approaches (characterization of HFE promoter, biochemistry of HFE, iron metabolism exploration, cellular employ) will be combined for a comprehensive resolution of iron metabolism control. A particular effort to dissect the connections that exists between iron metabolism, HFE, and immune system, will be made. Experimental tools and gained knowledge will be utilized to explore human pathological situations associated with iron disorders, their early diagnosis and the development of novel therapeutic modalities.
Fields of science (EuroSciVoc)
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
- natural sciences biological sciences microbiology virology
- medical and health sciences health sciences infectious diseases
- medical and health sciences basic medicine immunology
- medical and health sciences basic medicine pathology
- medical and health sciences basic medicine physiology homeostasis
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Programme(s)
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Topic(s)
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Call for proposal
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
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Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
Funding Scheme
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Coordinator
75724 PARIS
France
The total costs incurred by this organisation to participate in the project, including direct and indirect costs. This amount is a subset of the overall project budget.