Objective
Leukocyte extravasation is a critical process in inflammation, and its derangement is pathogenic in many human diseases. Goal of this project is the molecular dissection of leukocyte-EC contact-dependent signalling pathways involved in promoting leukocyte extravasation. Specific aims to be achieved are: to investigate the mechanistic basis of chemokine-induced leukocyte responses functionally associated with the extravasation process; to analyse the role of EC molecules engaged in leukocyte adhesion in promoting contact dependant EC activation and in controlling contiguous EC barrier function during leukocyte transmigration; to develop strategies based on short term genetic or biochemical modifications of the endothelium in vivo to modulate leukocyte extravasation. The results should provide the basic knowledge to develop novel therapeutic tools for the modulation of transendothelial migration by circulating leukocytes.
Call for proposal
Data not availableFunding Scheme
CSC - Cost-sharing contractsCoordinator
20132 MILANO
Italy