Objective
Leukocyte extravasation is a critical process in inflammation, and its derangement is pathogenic in many human diseases. Goal of this project is the molecular dissection of leukocyte-EC contact-dependent signalling pathways involved in promoting leukocyte extravasation. Specific aims to be achieved are: to investigate the mechanistic basis of chemokine-induced leukocyte responses functionally associated with the extravasation process; to analyse the role of EC molecules engaged in leukocyte adhesion in promoting contact dependant EC activation and in controlling contiguous EC barrier function during leukocyte transmigration; to develop strategies based on short term genetic or biochemical modifications of the endothelium in vivo to modulate leukocyte extravasation. The results should provide the basic knowledge to develop novel therapeutic tools for the modulation of transendothelial migration by circulating leukocytes.
Fields of science (EuroSciVoc)
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Programme(s)
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Topic(s)
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Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Call for proposal
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
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Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
Funding Scheme
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Coordinator
20132 MILANO
Italy
The total costs incurred by this organisation to participate in the project, including direct and indirect costs. This amount is a subset of the overall project budget.