European network to develop genetic markers for essential hypertension

Objective

We propose to form a consortium of cardiovascular clinicians, molecular geneticists and epidemiologists to develop molecular markers of cardiovascular disease that will be used for diagnosis and prognosis in essential hypertension and its end-organ damage. The overall aim will be to use these markers as early diagnostic tests for the identification of high-risk populations and for designing new preventive and therapeutic measures. This project will combine high fidelity phenotyping, high throughput genotyping with 5000 single nucleotide polymorphisms and sophisticated statistical strategies. We will be able to identify genes causally related to hypertension and its complications and thus improve the ability of the European Community to introduce prophylactic and therapeutics measures to reduce the epidemic of cardiovascular disease.

Fields of science

• medical and health sciences › clinical medicine › cardiology › cardiovascular diseases
• natural sciences › biological sciences › genetics › nucleotides

Programme(s)

• FP5-LIFE QUALITY - Specific Programme for research, technological development and demonstration on "Quality of life and management of living resources", 1998-2002

Topic(s)

• 1.1.1.-7. - Chronic and degenerative diseases, cancer, diabetes, cardivascular diseases and rare diseases

Call for proposal

Data not available

Funding Scheme

CSC - Cost-sharing contracts

Coordinator

UNIVERSITY OF GLASGOW

Address

University Avenue
G12 8QQ Glasgow
United Kingdom

Participants (5)

INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE

France

Address

Rue D'ulm 3 Adr 6 - Paris Saint-antoine Collège
75005 Paris

KATHOLIEKE UNIVERSITEIT LEUVEN

Belgium

Address

49,herestraat 49
3000 Louvain / Leuven

MAX DELBRUCK CENTER FOR MOLECULAR MEDICINE

Germany

Address

Robert-roessle-strasse 10
13092 Berlin

Queen Mary and Westfield College

United Kingdom

Address

Mile End Road
E1 4NS London

UNIVERSITA VITA-SALUTE SAN RAFFAELE

Italy

Address

Via Olgettina 58
20132 Milano