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European network to develop genetic markers for essential hypertension

Objective

We propose to form a consortium of cardiovascular clinicians, molecular geneticists and epidemiologists to develop molecular markers of cardiovascular disease that will be used for diagnosis and prognosis in essential hypertension and its end-organ damage. The overall aim will be to use these markers as early diagnostic tests for the identification of high-risk populations and for designing new preventive and therapeutic measures. This project will combine high fidelity phenotyping, high throughput genotyping with 5000 single nucleotide polymorphisms and sophisticated statistical strategies. We will be able to identify genes causally related to hypertension and its complications and thus improve the ability of the European Community to introduce prophylactic and therapeutics measures to reduce the epidemic of cardiovascular disease.

Funding Scheme

CSC - Cost-sharing contracts

Coordinator

UNIVERSITY OF GLASGOW
Address
University Avenue
G12 8QQ Glasgow
United Kingdom

Participants (5)

INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE
France
Address
Rue D'ulm 3 Adr 6 - Paris Saint-antoine Collège
75005 Paris
KATHOLIEKE UNIVERSITEIT LEUVEN
Belgium
Address
49,Herestraat 49
3000 Louvain / Leuven
MAX DELBRUCK CENTER FOR MOLECULAR MEDICINE
Germany
Address
Robert-roessle-strasse 10
13092 Berlin
Queen Mary and Westfield College
United Kingdom
Address
Mile End Road
E1 4NS London
UNIVERSITA VITA-SALUTE SAN RAFFAELE
Italy
Address
Via Olgettina 58
20132 Milano