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Concerted action on mitochondrial biogenesis and disease

Objective

Mitochondria are at the core of cellular metabolism; hence it is not surprising that mitochondrial dysfunction is a frequent cause of human disease. This proposal establishes a consortium of 51 European research teams from diverse disciplines, to elucidate the pathogenic mechanisms involved in these disorders This will involve a combined effort to characterize the components of the apparatus of mitochondrial biogenesis (mtDNA replication, transcription, translation, RNA processing, assembly and transport) in key model organisms, to establish and exploit pathogenic models in cell culture and in whole organisms, and to develop techniques for manipulating mitochondrial gene expression, aimed at eventual therapy. The consortium will facilitate this research effort by pooling research tools and resources, promoting researcher exchanges and training, and enhancing scientific communication between scientists with complementary expertise.

Funding Scheme

CON - Coordination of research actions

Coordinator

UNIVERSITY OF TAMPERE
Address
6,Lenkkeilijänkatu 6
33014 Tampere
Finland

Participants (40)

CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE
France
Address
Rue Rent Descartes 21
67084 Strasbourg
CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE
France
Address
Rue De Général Zimmer 12
67084 Strasbourg
CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE
France
Address
Avenue De La Terrasse, Bftiment 26
91198 Gif Sur Yvette
CONSEJO SUPERIOR DE INVESTIGACIONES CIENTIFICAS
Spain
Address
4,Arturo Duperier 4
28029 Madrid
DRESDEN UNIVERSITY OF TECHNOLOGY
Germany
Address
Mommsenstrasse 13
01062 Dresden
GOETEBORG UNIVERSITY
Sweden
Address
Sahlgrenska University Hospital
413 45 Goeteborg
GSF-RESEARCH CENTER FOR ENVIRONMENT AND HEALTH
Germany
Address
Ingolstaedter Landstrasse 1
85764 Oberschleissheim
HEINRICH-HEINE-UNIVERSITAET DUESSELDORF
Germany
Address
Universitaetstrasse 1
40225 Duesseldorf
INSTITUT CATALA DE LA SALUT
Spain
Address
Paseo Valle De Hebron 119-129, Planta Baixa
08035 Barcelona
INSTITUT NATIONAL DE LA RECHERCHE AGRONOMIQUE
France
Address
Place Pierre Viala 2
34060 Montpellier
INSTITUT NATIONAL DE LA RECHERCHE AGRONOMIQUE
France
Address
Rue Gaston Crémieux 2, Route De Saint Cyr
91057 Evry
INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE
France
Address
Rue De Sèvres 149
75743 Paris
INSTITUTE OF BIOCHEMISTRY AND BIOPHYSICS - POLISH ACADEMY OF SCIENCES
Poland
Address
36,Pawinskiego 5A
02-106 Warszawa
ISTITUTO NAZIONALE NEUROLOGICO 'CARLO BESTA'
Italy
Address
Via Celoria 11
20133 Milano
KAROLINSKA INSTITUTE
Sweden
Address
Karolinska Hospital
171 76 Stockholm
MEDICAL RESEARCH COUNCIL
United Kingdom
Address
Welcome Trust, Mrc Building, Hills Road
CB2 2XY Cambridge
PHILIPPS UNIVERSITY MARBURG
Germany
Address
Robert-koch-strasse 5
35033 Marburg
STICHTING KATHOLIEKE UNIVERSITEIT
Netherlands
Address
Geert Grooteplein 10
6500 HB Nijmegen
THE CHANCELLOR, MASTERS AND SCHOLARS OF THE UNIVERSITY OF OXFORD
United Kingdom
Address
South Parks Road
OX1 3RB Oxford
UNIVERSIDAD AUTONOMA DE MADRID
Spain
Address
Facultad De Ciencias Cantoblanco
28049 Madrid
UNIVERSIDAD DE ZARAGOZA
Spain
Address
177,Miguel Servet 177
50013 Zaragoza
UNIVERSIT BLAISE PASCAL CLERMONT-FERRAND II
France
Address
Avenue Des Landais 24
63177 Aubiere
UNIVERSIT DEGLI STUDI DI PALERMO
Italy
Address
Viale Delle Scienze, Parco D'orleans
90128 Palermo
UNIVERSITA DEGLI STUDI DI BARI
Italy
Address
Via E. Orabona 4
70125 Bari
UNIVERSITA DEGLI STUDI DI PADOVA
Italy
Address
Via Giustiniani 5
35128 Padova
UNIVERSITAET KOELN
Germany
Address
Robert-koch-strasse 39
50931 Koeln
UNIVERSITAT DE BARCELONA
Spain
Address
Avda Diagonal 645
08028 Barcelona
UNIVERSITE CATHOLIQUE DE LOUVAIN
Belgium
Address
2/20,Place Croix Du Sud 2/20
1348 Louvain-la-neuve
UNIVERSITE DE PARIS-SUD XI
France
Address
Rue Georges Clemenceau 15, Bftiment 400
91405 Gometz La Ville
UNIVERSITE DE VERSAILLES SAINT QUENTIN EN YVELINE
France
Address
Rue Du Refuge 23
78035 Versailles
UNIVERSITEIT VAN AMSTERDAM
Netherlands
Address
Kruislaan 318
1098 SM Amsterdam
UNIVERSITY MEDICAL SCHOOL OF PECS
Hungary
Address
Szigeti Ut 12
7624 Pecs
UNIVERSITY OF BERGEN
Norway
Address
Haukeland Hospital
5021 Bergen
UNIVERSITY OF FRIBOURG
Switzerland
Address
Chemin Du Musee 10
1700 Fribourg
UNIVERSITY OF MAASTRICHT
Netherlands
Address
Joseph Bechlaan 113
6201 BL Maastricht
UNIVERSITY OF NEWCASTLE UPON TYNE
United Kingdom
Address
Framlington Place
NE2 4HH Newcastle Upon Tyne
UNIVERSITY OF ROME "LA SAPIENZA"
Italy
Address
Piazzale Aldo Moro 5
00185 Roma
UNIVERSITY OF ULM
Germany
Address
Albert-einstein-allee 11
89081 Ulm
UNIVERSITY OF VIENNA
Austria
Address
9,Dr. Bohrgasse 9
1030 Wien
UNIVERSITY OF WUERZBURG
Germany
Address
Am Hubland
97074 Wuerzburg