Objective
Mitochondria are at the core of cellular metabolism; hence it is not surprising that mitochondrial dysfunction is a frequent cause of human disease. This proposal establishes a consortium of 51 European research teams from diverse disciplines, to elucidate the pathogenic mechanisms involved in these disorders This will involve a combined effort to characterize the components of the apparatus of mitochondrial biogenesis (mtDNA replication, transcription, translation, RNA processing, assembly and transport) in key model organisms, to establish and exploit pathogenic models in cell culture and in whole organisms, and to develop techniques for manipulating mitochondrial gene expression, aimed at eventual therapy. The consortium will facilitate this research effort by pooling research tools and resources, promoting researcher exchanges and training, and enhancing scientific communication between scientists with complementary expertise.
Call for proposal
Data not availableFunding Scheme
CON - Coordination of research actionsCoordinator
33014 Tampere
Finland
Participants (40)
67084 Strasbourg
67084 Strasbourg
91198 Gif Sur Yvette
28029 Madrid
01062 Dresden
413 45 Goeteborg
85764 Oberschleissheim
40225 Duesseldorf
08035 Barcelona
34060 Montpellier
91057 Evry
75743 Paris
02-106 Warszawa
20133 Milano
171 76 Stockholm
CB2 2XY Cambridge
35033 Marburg
6500 HB Nijmegen
OX1 3RB Oxford
28049 Madrid
50013 Zaragoza
63177 Aubiere
90128 Palermo
70125 Bari
35128 Padova
50931 Koeln
08028 Barcelona
1348 Louvain-la-neuve
91405 Gometz La Ville
78035 Versailles
1098 SM Amsterdam
7624 Pecs
5021 Bergen
1700 Fribourg
6201 BL Maastricht
NE2 4HH Newcastle Upon Tyne
00185 Roma
89081 Ulm
1030 Wien
97074 Wuerzburg