Concerted action on mitochondrial biogenesis and disease

Objective

Mitochondria are at the core of cellular metabolism; hence it is not surprising that mitochondrial dysfunction is a frequent cause of human disease. This proposal establishes a consortium of 51 European research teams from diverse disciplines, to elucidate the pathogenic mechanisms involved in these disorders This will involve a combined effort to characterize the components of the apparatus of mitochondrial biogenesis (mtDNA replication, transcription, translation, RNA processing, assembly and transport) in key model organisms, to establish and exploit pathogenic models in cell culture and in whole organisms, and to develop techniques for manipulating mitochondrial gene expression, aimed at eventual therapy. The consortium will facilitate this research effort by pooling research tools and resources, promoting researcher exchanges and training, and enhancing scientific communication between scientists with complementary expertise.

Programme(s)

• FP5-LIFE QUALITY - Specific Programme for research, technological development and demonstration on "Quality of life and management of living resources", 1998-2002

Topic(s)

• 1.1.1.-7. - Chronic and degenerative diseases, cancer, diabetes, cardivascular diseases and rare diseases

Funding Scheme

CON - Coordination of research actions

Coordinator

UNIVERSITY OF TAMPERE

Address

6,Lenkkeilijänkatu 6
33014 Tampere
Finland

Participants (40)

CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE

France

Address

Rue Rent Descartes 21
67084 Strasbourg

CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE

France

Address

Rue De Général Zimmer 12
67084 Strasbourg

CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE

France

Address

Avenue De La Terrasse, Bftiment 26
91198 Gif Sur Yvette

CONSEJO SUPERIOR DE INVESTIGACIONES CIENTIFICAS

Spain

Address

4,Arturo Duperier 4
28029 Madrid

DRESDEN UNIVERSITY OF TECHNOLOGY

Germany

Address

Mommsenstrasse 13
01062 Dresden

GOETEBORG UNIVERSITY

Sweden

Address

Sahlgrenska University Hospital
413 45 Goeteborg

GSF-RESEARCH CENTER FOR ENVIRONMENT AND HEALTH

Germany

Address

Ingolstaedter Landstrasse 1
85764 Oberschleissheim

HEINRICH-HEINE-UNIVERSITAET DUESSELDORF

Germany

Address

Universitaetstrasse 1
40225 Duesseldorf

INSTITUT CATALA DE LA SALUT

Spain

Address

Paseo Valle De Hebron 119-129, Planta Baixa
08035 Barcelona

INSTITUT NATIONAL DE LA RECHERCHE AGRONOMIQUE

France

Address

Place Pierre Viala 2
34060 Montpellier

INSTITUT NATIONAL DE LA RECHERCHE AGRONOMIQUE

France

Address

Rue Gaston Crémieux 2, Route De Saint Cyr
91057 Evry

INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE

France

Address

Rue De Sèvres 149
75743 Paris

INSTITUTE OF BIOCHEMISTRY AND BIOPHYSICS - POLISH ACADEMY OF SCIENCES

Poland

Address

36,Pawinskiego 5A
02-106 Warszawa

ISTITUTO NAZIONALE NEUROLOGICO 'CARLO BESTA'

Italy

Address

Via Celoria 11
20133 Milano

KAROLINSKA INSTITUTE

Sweden

Address

Karolinska Hospital
171 76 Stockholm

MEDICAL RESEARCH COUNCIL

United Kingdom

Address

Welcome Trust, Mrc Building, Hills Road
CB2 2XY Cambridge

PHILIPPS UNIVERSITY MARBURG

Germany

Address

Robert-koch-strasse 5
35033 Marburg

STICHTING KATHOLIEKE UNIVERSITEIT

Netherlands

Address

Geert Grooteplein 10
6500 HB Nijmegen

THE CHANCELLOR, MASTERS AND SCHOLARS OF THE UNIVERSITY OF OXFORD

United Kingdom

Address

South Parks Road
OX1 3RB Oxford

UNIVERSIDAD AUTONOMA DE MADRID

Spain

Address

Facultad De Ciencias Cantoblanco
28049 Madrid

UNIVERSIDAD DE ZARAGOZA

Spain

Address

177,Miguel Servet 177
50013 Zaragoza

UNIVERSIT BLAISE PASCAL CLERMONT-FERRAND II

France

Address

Avenue Des Landais 24
63177 Aubiere

UNIVERSIT DEGLI STUDI DI PALERMO

Italy

Address

Viale Delle Scienze, Parco D'orleans
90128 Palermo

UNIVERSITA DEGLI STUDI DI BARI

Italy

Address

Via E. Orabona 4
70125 Bari

UNIVERSITA DEGLI STUDI DI PADOVA

Italy

Address

Via Giustiniani 5
35128 Padova

UNIVERSITAET KOELN

Germany

Address

Robert-koch-strasse 39
50931 Koeln

UNIVERSITAT DE BARCELONA

Spain

Address

Avda Diagonal 645
08028 Barcelona

UNIVERSITE CATHOLIQUE DE LOUVAIN

Belgium

Address

2/20,Place Croix Du Sud 2/20
1348 Louvain-la-neuve

UNIVERSITE DE PARIS-SUD XI

France

Address

Rue Georges Clemenceau 15, Bftiment 400
91405 Gometz La Ville

UNIVERSITE DE VERSAILLES SAINT QUENTIN EN YVELINE

France

Address

Rue Du Refuge 23
78035 Versailles

UNIVERSITEIT VAN AMSTERDAM

Netherlands

Address

Kruislaan 318
1098 SM Amsterdam

UNIVERSITY MEDICAL SCHOOL OF PECS

Hungary

Address

Szigeti Ut 12
7624 Pecs

UNIVERSITY OF BERGEN

Norway

Address

Haukeland Hospital
5021 Bergen

UNIVERSITY OF FRIBOURG

Switzerland

Address

Chemin Du Musee 10
1700 Fribourg

UNIVERSITY OF MAASTRICHT

Netherlands

Address

Joseph Bechlaan 113
6201 BL Maastricht

UNIVERSITY OF NEWCASTLE UPON TYNE

United Kingdom

Address

Framlington Place
NE2 4HH Newcastle Upon Tyne

UNIVERSITY OF ROME "LA SAPIENZA"

Italy

Address

Piazzale Aldo Moro 5
00185 Roma

UNIVERSITY OF ULM

Germany

Address

Albert-einstein-allee 11
89081 Ulm

UNIVERSITY OF VIENNA

Austria

Address

9,Dr. Bohrgasse 9
1030 Wien

UNIVERSITY OF WUERZBURG

Germany

Address

Am Hubland
97074 Wuerzburg