Objective
Mitochondria are at the core of cellular metabolism; hence it is not surprising that mitochondrial dysfunction is a frequent cause of human disease. This proposal establishes a consortium of 51 European research teams from diverse disciplines, to elucidate the pathogenic mechanisms involved in these disorders This will involve a combined effort to characterize the components of the apparatus of mitochondrial biogenesis (mtDNA replication, transcription, translation, RNA processing, assembly and transport) in key model organisms, to establish and exploit pathogenic models in cell culture and in whole organisms, and to develop techniques for manipulating mitochondrial gene expression, aimed at eventual therapy. The consortium will facilitate this research effort by pooling research tools and resources, promoting researcher exchanges and training, and enhancing scientific communication between scientists with complementary expertise.
Fields of science
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques.
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques.
Call for proposal
Data not availableFunding Scheme
CON - Coordination of research actionsCoordinator
33014 TAMPERE
Finland
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Participants (40)
67084 STRASBOURG
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67084 STRASBOURG
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91198 GIF SUR YVETTE
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28029 MADRID
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01062 DRESDEN
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413 45 GOETEBORG
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85764 OBERSCHLEISSHEIM
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40225 DUESSELDORF
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08035 BARCELONA
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34060 Montpellier
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91057 EVRY
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75743 PARIS
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02-106 WARSZAWA
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20133 MILANO
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171 76 STOCKHOLM
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CB2 2XY CAMBRIDGE
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35033 MARBURG
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6500 HB NIJMEGEN
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OX1 3RB OXFORD
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28049 MADRID
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50013 ZARAGOZA
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63177 AUBIERE
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90128 PALERMO
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70125 BARI
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35128 PADOVA
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50931 KOELN
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08028 BARCELONA
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1348 LOUVAIN-LA-NEUVE
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91405 GOMETZ LA VILLE
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78035 VERSAILLES
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1098 SM AMSTERDAM
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7624 PECS
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5021 BERGEN
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1700 FRIBOURG
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6201 BL MAASTRICHT
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NE2 4HH NEWCASTLE UPON TYNE
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00185 ROMA
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89081 ULM
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1030 WIEN
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97074 WUERZBURG
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