Objective Mutations in the Cystic Fibrosis Transmembrane Conductance Regulator (CFTR) affect the maturation and trafficking of the protein in the cell or cause dysfunction of this cell surface expressed chloride channel. To rescue the cells, compounds will be designed capable of correcting the processing and dysfunction of CFTR. In addition known interacting proteins and novel interacting proteins, identified during the proposed investigations will be characterized at the genetic, biochemical and electrophysiological level and their ability to compensate for or rescue the cells from dysfunction will be determined (in combination with selective compounds) . The thus identified protein network should contribute to the understanding of the clinical variation observed in affected sibs, the role of similar mutations in the frequent CF related diseases and could provide tools to diagnose, monitor and treat these diseases. Fields of science natural sciencesbiological sciencesbiochemistrybiomoleculesproteinsnatural sciencesbiological sciencesgeneticsmutation Programme(s) FP5-LIFE QUALITY - Specific Programme for research, technological development and demonstration on "Quality of life and management of living resources", 1998-2002 Topic(s) 1.1.1.-7. - Chronic and degenerative diseases, cancer, diabetes, cardivascular diseases and rare diseases Call for proposal Data not available Funding Scheme CSC - Cost-sharing contracts Coordinator KATHOLIEKE UNIVERSITEIT LEUVEN EU contribution No data Address 49,Herestraat 49 3000 LOUVAIN / LEUVEN Belgium See on map Total cost No data Participants (7) Sort alphabetically Sort by EU Contribution Expand all Collapse all Clondiag Chip Technologies GmbH Germany EU contribution No data Address Loebstedter Strasse 103-105 07749 Jena See on map Links Website Opens in new window Total cost No data ERASMUS UNIVERSITEIT ROTTERDAM Netherlands EU contribution No data Address Dr Molewaterplein 50 3000 DR ROTTERDAM See on map Total cost No data EUROGENTEC SA Belgium EU contribution No data Address Rue Bois Saint Jean 14 4102 OUGREE See on map Total cost No data HANNOVER MEDICAL SCHOOL Germany EU contribution No data Address Carl-Neuberg-Strasse 1 30625 HANNOVER See on map Total cost No data KLINIKUM DER FRIEDRICH-SCHILLER-UNIVERSITAET JENA Germany EU contribution No data Address Erlanger Allee 101 07747 JENA See on map Total cost No data UNIVERSITE DE POITIERS France EU contribution No data Address Avenue du Recteur Pineau, 40 86022 POITIERS See on map Total cost No data UNIVERSITY OF BRISTOL United Kingdom EU contribution No data Address University Walk BS8 1TD BRISTOL, CLIFTON See on map Total cost No data
