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Environmental factors, helicobacter pylori infection, genetic suceptibility and the gastric cancer risk in the european population (EUR-GAST)

Objective

Helicobacter pylori (Hp) infection is an important cause of gastric cancer (GC), duodenal and gastric ulcer, and gastric lymphoma. Factors affecting progression, pathways and outcomes of this process are not known. Vegetables and fruits are associated with GC, but the mechanism of action remains unknown. Role of nutrients, alcohol and tobacco has not been established. Genetic susceptibility may influence individual responses to these factors explaining why only a minority infected persons developed GC. In a multicenter prospective study carried out in nine European countries, a nested case-control study will be conducted aimed to elucidate the individual and joint effects of Hp infection, genetic polymorphisms, nutritional status and environmental factors putatively involved in the aetiology of GC in the European population.

Call for proposal

Data not available
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Coordinator

INSTITUT CATALA D'ONCOLOGIA
Address
Avenida gran via km 2.7
08907 Hospitalet del llobregat
Spain

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EU contribution
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Participants (4)