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Environmental factors, helicobacter pylori infection, genetic suceptibility and the gastric cancer risk in the european population (EUR-GAST)

Objective

Helicobacter pylori (Hp) infection is an important cause of gastric cancer (GC), duodenal and gastric ulcer, and gastric lymphoma. Factors affecting progression, pathways and outcomes of this process are not known. Vegetables and fruits are associated with GC, but the mechanism of action remains unknown. Role of nutrients, alcohol and tobacco has not been established. Genetic susceptibility may influence individual responses to these factors explaining why only a minority infected persons developed GC. In a multicenter prospective study carried out in nine European countries, a nested case-control study will be conducted aimed to elucidate the individual and joint effects of Hp infection, genetic polymorphisms, nutritional status and environmental factors putatively involved in the aetiology of GC in the European population.

Funding Scheme

CSC - Cost-sharing contracts

Coordinator

INSTITUT CATALA D'ONCOLOGIA
Address
Avenida Gran Via Km 2.7
08907 Hospitalet Del Llobregat
Spain

Participants (4)

CENTRO PER LO STUDIO E LA PREVENZIONE ONCOLOGICA
Italy
Address
Via Di San Salvi 12
50135 Firenze
CHIRON S.R.L.
Italy
Address
Via Fiorentina 1
53100 Siena
INTERNATIONAL AGENCY FOR RESEARCH ON CANCER
France
Address
Cours Albert-thomas 150
69372 Lyon
THE CHANCELLOR, MASTERS AND SCHOLARS OF THE UNIVERSITY OF CAMBRIDGE
United Kingdom
Address
Hills Road
CB2 2QQ Cambridge