Helicobacter pylori (Hp) infection is an important cause of gastric cancer (GC), duodenal and gastric ulcer, and gastric lymphoma. Factors affecting progression, pathways and outcomes of this process are not known. Vegetables and fruits are associated with GC, but the mechanism of action remains unknown. Role of nutrients, alcohol and tobacco has not been established. Genetic susceptibility may influence individual responses to these factors explaining why only a minority infected persons developed GC. In a multicenter prospective study carried out in nine European countries, a nested case-control study will be conducted aimed to elucidate the individual and joint effects of Hp infection, genetic polymorphisms, nutritional status and environmental factors putatively involved in the aetiology of GC in the European population.
Funding SchemeCSC - Cost-sharing contracts
CB2 2QQ Cambridge