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Relationship between insulin sensitivity and cardiovascular disease risk

Objective

Insulin resistance is a key predictor for the development of type 2 diabetes mellitus and appears to be important in the pathogenesis of cardiovascular disease (CVD), which is the leading cause of morbidity and premature mortality in Europe, although prevalence rates differ between geographical regions. Type 2 diabetes, which enhances the risk of CVD 3- to 5- fold, was estimated by WHO to have a prevalence of 20-25 million in Europe in 1997. The degree of insulin resistance is influenced by multiple factors, including genetic and environmental factors (e.g. obesity and inactivity). This project will use the expertise and organisational infrastructure of an existing European collaborative research group to study 1500 healthy subjects. Baseline measurements will be made of insulin resistance, classical cardiovascular risk factors, glucose tolerance, candidate genotypes and CVD by carotid artery intima-media thickness. Investigations will be repeated after 3 years to define the relation between insulin resistance and the development of CVD and type 2 diabetes. This study will provide unique information on the importance of insulin resistance in the development of CVD and diabetes, and has implications for the development of prevention and treatment strategies relevant to Europe.

Funding Scheme

CSC - Cost-sharing contracts

Coordinator

UNIVERSITA DEGLI STUDI DI PISA
Address
Via Roma 67
56100 Pisa
Italy

Participants (15)

CATHOLIC UNIVERSITY OF SACRED HEART
Italy
Address
Largo Agostino Gemelli 8
00168 Roma
CENTRE DE RECHERCHE EN NUTRITION HUMAINE DE LYON
France
Address
Place D'arsonval
69437 Lyon
CHARITABLE FOUNDATION HENRI DUNANT
Greece
Address
107 Messogion Avenue
11526 Athens
HAUGHTON INSTITUTE FOR GRADUATE EDUCATION AND TRAINING IN THE HEALTH SCIENCES LIMITED
Ireland
Address
St James's Hospital
8 Dublin
HOPITAL CANTONAL UNIVERSITAIRE DE GENEVE
Switzerland
Address
Rue Micheli-du-crest 24
1211 Geneve
HOSPITAL UNIVERSITARIO LA PAZ
Spain
Address
Paseo De La Castellana 261
28046 Madrid
INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE
France
Address
Avenue Paul Vaillant Couturier
94807 Villejuif
KUOPIO UNIVERSITY HOSPITAL
Finland
Address
Puijonlaaksontie 2
70210 Kuopio
MEDICAL UNIVERSITY OF VIENNA
Austria
Address
Waehringer Guertel 18-20
1090 Wien
NATIONAL RESEARCH COUNCIL OF ITALY
Italy
Address
Corso Stati Uniti 4
35127 Padova
ODENSE UNIVERSITY HOSPITAL
Denmark
Address
Sdr. Boulevard 29
5000 Odense
UNIVERSITA DEGLI STUDI DI PERUGIA
Italy
Address
Via Enrico Dal Pozzo
06126 Perugia
UNIVERSITY OF GLASGOW
United Kingdom
Address
Glasgow Royal Infirmary - Queen Elizabeth Building
G31 2ER Glasgow
UNIVERSITY OF NEWCASTLE UPON TYNE
United Kingdom
Address
Framlington Place
NE2 4HH Newcastle Upon Tyne
VRIJE UNIVERSITEIT MEDICAL CENTER
Netherlands
Address
Van Der Boechorststraat 7
1081 BT Amsterdam