Insulin resistance is a key predictor for the development of type 2 diabetes mellitus and appears to be important in the pathogenesis of cardiovascular disease (CVD), which is the leading cause of morbidity and premature mortality in Europe, although prevalence rates differ between geographical regions. Type 2 diabetes, which enhances the risk of CVD 3- to 5- fold, was estimated by WHO to have a prevalence of 20-25 million in Europe in 1997. The degree of insulin resistance is influenced by multiple factors, including genetic and environmental factors (e.g. obesity and inactivity). This project will use the expertise and organisational infrastructure of an existing European collaborative research group to study 1500 healthy subjects. Baseline measurements will be made of insulin resistance, classical cardiovascular risk factors, glucose tolerance, candidate genotypes and CVD by carotid artery intima-media thickness. Investigations will be repeated after 3 years to define the relation between insulin resistance and the development of CVD and type 2 diabetes. This study will provide unique information on the importance of insulin resistance in the development of CVD and diabetes, and has implications for the development of prevention and treatment strategies relevant to Europe.
Funding SchemeCSC - Cost-sharing contracts
G31 2ER Glasgow
NE2 4HH Newcastle Upon Tyne
1081 BT Amsterdam