Objective Glucocorticoid (GC) -induced apoptosis, although frequently not recognized, is a poorly understood phenomenon of major clinical significance: First, it is a central component in the treatment of lymphoid malignancies. Second, through its postulated effect upon immune repertoire generation, it might contribute to the pathogenesis of autoimmune diseases. We propose to investigate(a) the molecular basis of GC-induced apoptosis,(b ) mechanisms of the therapeutically important GC resistance, and ( c ) the role of these phenomena in autoimmune disease pathogenesis, thereby providing the basis for improved therapy of lymphoid malignancies and perhaps autoimmune disorders. The research will be performed by combining the expertise of clinical and basic scientists from 5 internationally renowned groups that will exploit functional genomics and other molecular techniques to analyse normal and malignant lymphocytes from afflicted patients, and from genetically modified and spontaneously autoimmune mice. Fields of science natural sciencesbiological sciencesgeneticsmedical and health sciencesbasic medicineimmunologyautoimmune diseases Programme(s) FP5-LIFE QUALITY - Specific Programme for research, technological development and demonstration on "Quality of life and management of living resources", 1998-2002 Topic(s) 1.1.1.-7. - Chronic and degenerative diseases, cancer, diabetes, cardivascular diseases and rare diseases Call for proposal Data not available Funding Scheme CSC - Cost-sharing contracts Coordinator N/A Address See on map EU contribution € 0,00 Participants (3) Sort alphabetically Sort by EU Contribution Expand all Collapse all GERMAN CANCER RESEARCH CENTER Germany EU contribution € 0,00 Address Im neuenheimer feld 280 69120 Heidelberg See on map KAROLINSKA INSTITUTE Sweden EU contribution € 0,00 Address Novum huddinge sjukhus 141 86 Huddinge See on map LEOPOLD-FRANZENS-UNIVERSITAET INNSBRUCK Austria EU contribution € 0,00 Address 3/iv,fritz-pregl-strasse 3 6020 Innsbruck See on map
