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Glucocorticoid-induced apoptosis and glucocorticoid resistance in lymphoid malignancies and autoimmune diseases (EUGIA)

Objective

Glucocorticoid (GC) -induced apoptosis, although frequently not recognized, is a poorly understood phenomenon of major clinical significance: First, it is a central component in the treatment of lymphoid malignancies. Second, through its postulated effect upon immune repertoire generation, it might contribute to the pathogenesis of autoimmune diseases. We propose to investigate
(a) the molecular basis of GC-induced apoptosis,
(b ) mechanisms of the therapeutically important GC resistance, and
( c ) the role of these phenomena in autoimmune disease pathogenesis, thereby providing the basis for improved therapy of lymphoid malignancies and perhaps autoimmune disorders. The research will be performed by combining the expertise of clinical and basic scientists from 5 internationally renowned groups that will exploit functional genomics and other molecular techniques to analyse normal and malignant lymphocytes from afflicted patients, and from genetically modified and spontaneously autoimmune mice.

Funding Scheme

CSC - Cost-sharing contracts

Coordinator

N/A

Participants (3)

GERMAN CANCER RESEARCH CENTER
Germany
Address
Im Neuenheimer Feld 280
69120 Heidelberg
KAROLINSKA INSTITUTE
Sweden
Address
Novum Huddinge Sjukhus
141 86 Huddinge
LEOPOLD-FRANZENS-UNIVERSITAET INNSBRUCK
Austria
Address
3/Iv,fritz-pregl-strasse 3
6020 Innsbruck