Objectif Glucocorticoid (GC) -induced apoptosis, although frequently not recognized, is a poorly understood phenomenon of major clinical significance: First, it is a central component in the treatment of lymphoid malignancies. Second, through its postulated effect upon immune repertoire generation, it might contribute to the pathogenesis of autoimmune diseases. We propose to investigate(a) the molecular basis of GC-induced apoptosis,(b ) mechanisms of the therapeutically important GC resistance, and ( c ) the role of these phenomena in autoimmune disease pathogenesis, thereby providing the basis for improved therapy of lymphoid malignancies and perhaps autoimmune disorders. The research will be performed by combining the expertise of clinical and basic scientists from 5 internationally renowned groups that will exploit functional genomics and other molecular techniques to analyse normal and malignant lymphocytes from afflicted patients, and from genetically modified and spontaneously autoimmune mice. Champ scientifique natural sciencesbiological sciencesgeneticsmedical and health sciencesbasic medicineimmunologyautoimmune diseases Programme(s) FP5-LIFE QUALITY - Specific Programme for research, technological development and demonstration on "Quality of life and management of living resources", 1998-2002 Thème(s) 1.1.1.-7. - Chronic and degenerative diseases, cancer, diabetes, cardivascular diseases and rare diseases Appel à propositions Data not available Régime de financement CSC - Cost-sharing contracts Coordinateur N/A Contribution de l’UE Aucune donnée Adresse Voir sur la carte Coût total Aucune donnée Participants (3) Trier par ordre alphabétique Trier par contribution de l’UE Tout développer Tout réduire GERMAN CANCER RESEARCH CENTER Allemagne Contribution de l’UE Aucune donnée Adresse Im Neuenheimer Feld 280 69120 HEIDELBERG Voir sur la carte Coût total Aucune donnée KAROLINSKA INSTITUTE Suède Contribution de l’UE Aucune donnée Adresse Novum Huddinge Sjukhus 141 86 Huddinge Voir sur la carte Coût total Aucune donnée LEOPOLD-FRANZENS-UNIVERSITAET INNSBRUCK Autriche Contribution de l’UE Aucune donnée Adresse 3/IV,Fritz-Pregl-Strasse 3 6020 INNSBRUCK Voir sur la carte Coût total Aucune donnée