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Generation and functional characterization of neuroendocrine cells for cellular replacement therapy (GROWBETA)

Objective

New insights into the molecular biology of signals, which control cellular function and differentiation, open novel approaches towards treatment of degenerative diseases. Diabetes mellitus is a prototype of such a disease, characterized either by a complete loss of the insulin producing B-cells or by impaired regulation of secretion. We want to combine the expertise of developmental biologists, neuroscientists, and cell biologists, to provide basic knowledge on how precursor cells can be induced to develop a secretory phenotype. Next, we want to study, how such cells are influenced in their function by a set of signals, which is shared by neurons and endocrine cells. Regarding diabetes, the challenge for cellular replacement therapy is not only to grow islet-like tissue, but also to achieve the uninterrupted control of blood glucose levels. The simplicity of islets should provide a testing ground for general strategies

Funding Scheme

CSC - Cost-sharing contracts

Coordinator

MAX-PLANCK-GESELLSCHAFT ZUR FOERDERUNG DER WISSENSCHAFTEN E.V.
Address
Waldweg 33
37073 Goettingen
Germany

Participants (5)

CELICA D.O.O.
Slovenia
Address
Stegne 21
1000 Ljubljana
DEVELOGEN AG
Germany
Address
Rudolf Wissel Strasse 28
37079 Goettingen
THE CHANCELLOR, MASTERS AND SCHOLARS OF THE UNIVERSITY OF OXFORD
United Kingdom
Address
Parks Road
OX1 3PT Oxford
UNIVERSITA VITA-SALUTE SAN RAFFAELE
Italy
Address
Via Olgettina 58
20132 Milano
UNIVERSITY OF GENEVA
Switzerland
Address
Rue Michel Servet 1
1211 Geneve