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An european network for myelofibrosis consensus on definition of disease improvement and biological impact of new therapies (EUMNET)

Objective

This project intends to provide a mechanism whereby new and promising approaches to the management of Myelofibrosis with Myeloid Metplasia (MMM)can be tested in a systematic and scientific manner. This objective will be the effort of a research network which first goal will be to offer to the scientific community a definition of improvement for MMM that will facilitate the standardization, conduct, interpretation and efficiency of clinical trials and might also be useful to physicians to decide how severe is the disease and if responded adequately to therapy in routine clinical practice. Selection of outcome variables through international surveys, and a combination of statistical and consensus techniques will be the methodologies used. Moreover, as a prototype of future studies, the role of cellular tyrosine kinase pathway in the myeloproliferation and the biological outcomes of a tyrosine kinase inhibitor, STI 571, will be evaluated.

Funding Scheme

CON - Coordination of research actions

Coordinator

IRCCS POLICLINICO SAN MATTEO - ISTITUTO DI RICOVERO E CURA A CARATTERE SCIENTIFICO
Address
Viale Golgi 19
27100 Pavia
Italy

Participants (12)

AVICENNE UNIVERSITY SCHOOL OF MEDICINE
France
Address
Boulevard General Leclerc
92118 Clichy
AZIENDA OSPEDALIERA OSPEDALE SAN MARTINO DI GENOVA E CLINICHE UNIVERSITARIE CONVENZIONATE
Italy
Address
Via Rosanna Benzi, 2
16132 Genova
FACULTE LIBRE DE MEDECINE
France
Address
Centre Hospitalier, Route De La Bassee
62307 Lens
HOSPITAL CLINIC BARCELONA
Spain
Address
Calle Villaroel 170
08036 Barcelona
INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE
France
Address
Avenue Paul Vaillant-couturier 14-16
94800 Villejuif
UNIVERSITAET KOELN
Germany
Address
Joseph-stelzmann-strasse 9
50924 Koeln
UNIVERSITE VICTOR SEGALEN - BORDEAUX II
France
Address
Leo Saignat 146, Bat. 1A Carreire Nord
33076 Bordeaux
UNIVERSITY HOSPITAL MERKUR ZAGREB
Croatia
Address
I. Zajca 19
10000 Zagreb
UNIVERSITY OF SHEFFIELD
United Kingdom
Address
Royal Hallamshire Hospital, Glossop Road
S10 2JN Sheffield
UNIVERSITY OF VIENNA
Austria
Address
Währinger Gürtel 18-20
1090 Wien
UNIVERSITÀ DEGLI STUDI DI BRESCIA
Italy
Address
Piazzale Spedali Civili 1
25123 Brescia
University of Ulm
Germany
Address
Albert-einstein-allee 11
89070 Ulm