An european network for myelofibrosis consensus on definition of disease improvement and biological impact of new therapies (EUMNET)

Objective

This project intends to provide a mechanism whereby new and promising approaches to the management of Myelofibrosis with Myeloid Metplasia (MMM)can be tested in a systematic and scientific manner. This objective will be the effort of a research network which first goal will be to offer to the scientific community a definition of improvement for MMM that will facilitate the standardization, conduct, interpretation and efficiency of clinical trials and might also be useful to physicians to decide how severe is the disease and if responded adequately to therapy in routine clinical practice. Selection of outcome variables through international surveys, and a combination of statistical and consensus techniques will be the methodologies used. Moreover, as a prototype of future studies, the role of cellular tyrosine kinase pathway in the myeloproliferation and the biological outcomes of a tyrosine kinase inhibitor, STI 571, will be evaluated.

Programme(s)

• FP5-LIFE QUALITY - Specific Programme for research, technological development and demonstration on "Quality of life and management of living resources", 1998-2002

Topic(s)

• 1.1.1.-7. - Chronic and degenerative diseases, cancer, diabetes, cardivascular diseases and rare diseases

Funding Scheme

Coordinator

Participants (12)