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Common molecular pathways in progression of kidney disease

Objective

Throughout Europe and over the world millions of people are affected by chronic renal failure leading to immense human suffering and an increasing economic burden. Research in recent years has indicated a common pathway responsible for progressive renal injury and end stage renal failure. Partial insight has been achieved in the role of a few molecules that represent snapshots in time of the complex, largely unknown regulatory pathways. In the concerted action on renal fibrosis and scarring (BMH4-CT98-3631) we have established a unique tissue bank of precious renal biopsies of patients with the most common causes of renal disease from expert centres of the European Union. It is the purpose of the present project to delineate the common molecular pathways of renal injury using state of the art genomics and protenomics approaches and design diagnostic tools to predict progression and prevent end stage renal failure.

Funding Scheme

CSC - Cost-sharing contracts

Coordinator

LEIDEN UNIVERSITY
Address
Albinusdreef 2
2333 ZA Leiden
Netherlands

Participants (12)

"NUOVA NEFROLOGIA" ASSOCIAZIONE PER L'AGGIORNAMENTO ET LA RICERCA
Italy
Address
Via Pio Ii 3 - C/o S.carlo Hospital
20153 Milano
AVENTIS PHARMA DEUTSCHLAND GMBH
Germany
Address
Industriepark Hoechst, 6879
65926 Frankfurt Am-main
FACULTY OF MEDICINE/UNIVERSITY HOSPITAL GOETTINGEN
Germany
Address
Robert-koch-strasse 40
37075 Goettingen
GERMAN CANCER RESEARCH CENTER
Germany
Address
Im Neuenheimer Feld 280
69120 Heidelberg
INFINEON TECHNOLOGIES AG
Germany
Address
Otto-hahn-ring 6
81739 Muenchen
INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE
France
Address
Hopital Tenon - Rue De La Chine 4
75020 Paris
LUDWIG-MAXIMILIANS UNIVERSITY OF MUNICH
Germany
Address
Schillerstrasse 42
80336 Muenchen
NATIONAL UNIVERSITY OF IRELAND, DUBLIN
Ireland
Address
Eccles Street 41
7 Dublin
UNIVERSIDAD AUTONOMA DE MADRID
Spain
Address
Arzobispo Morcillo N2
28029 Madrid
UNIVERSITA DEGLI STUDI DI BARI
Italy
Address
Piazza Giulio Cesare 11
70123 Bari
UNIVERSITY OF ABERDEEN
United Kingdom
Address
Polwarth Building, Foresterhill
AB25 2ZD Aberdeen
UNIVERSITY OF HELSINKI
Finland
Address
Haartmaninkatu 3
00014 Helsinki