Common molecular pathways in progression of kidney disease

Objective

Throughout Europe and over the world millions of people are affected by chronic renal failure leading to immense human suffering and an increasing economic burden. Research in recent years has indicated a common pathway responsible for progressive renal injury and end stage renal failure. Partial insight has been achieved in the role of a few molecules that represent snapshots in time of the complex, largely unknown regulatory pathways. In the concerted action on renal fibrosis and scarring (BMH4-CT98-3631) we have established a unique tissue bank of precious renal biopsies of patients with the most common causes of renal disease from expert centres of the European Union. It is the purpose of the present project to delineate the common molecular pathways of renal injury using state of the art genomics and protenomics approaches and design diagnostic tools to predict progression and prevent end stage renal failure.

Programme(s)

• FP5-LIFE QUALITY - Specific Programme for research, technological development and demonstration on "Quality of life and management of living resources", 1998-2002

Topic(s)

• 1.1.1.-7. - Chronic and degenerative diseases, cancer, diabetes, cardivascular diseases and rare diseases

Funding Scheme

CSC - Cost-sharing contracts

Coordinator

LEIDEN UNIVERSITY

Address

Albinusdreef 2
2333 ZA Leiden
Netherlands

Participants (12)

"NUOVA NEFROLOGIA" ASSOCIAZIONE PER L'AGGIORNAMENTO ET LA RICERCA

Italy

Address

Via Pio Ii 3 - C/o S.carlo Hospital
20153 Milano

AVENTIS PHARMA DEUTSCHLAND GMBH

Germany

Address

Industriepark Hoechst, 6879
65926 Frankfurt Am-main

FACULTY OF MEDICINE/UNIVERSITY HOSPITAL GOETTINGEN

Germany

Address

Robert-koch-strasse 40
37075 Goettingen

GERMAN CANCER RESEARCH CENTER

Germany

Address

Im Neuenheimer Feld 280
69120 Heidelberg

INFINEON TECHNOLOGIES AG

Germany

Address

Otto-hahn-ring 6
81739 Muenchen

INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE

France

Address

Hopital Tenon - Rue De La Chine 4
75020 Paris

LUDWIG-MAXIMILIANS UNIVERSITY OF MUNICH

Germany

Address

Schillerstrasse 42
80336 Muenchen

NATIONAL UNIVERSITY OF IRELAND, DUBLIN

Ireland

Address

Eccles Street 41
7 Dublin

UNIVERSIDAD AUTONOMA DE MADRID

Spain

Address

Arzobispo Morcillo N2
28029 Madrid

UNIVERSITA DEGLI STUDI DI BARI

Italy

Address

Piazza Giulio Cesare 11
70123 Bari

UNIVERSITY OF ABERDEEN

United Kingdom

Address

Polwarth Building, Foresterhill
AB25 2ZD Aberdeen

UNIVERSITY OF HELSINKI

Finland

Address

Haartmaninkatu 3
00014 Helsinki