Throughout Europe and over the world millions of people are affected by chronic renal failure leading to immense human suffering and an increasing economic burden. Research in recent years has indicated a common pathway responsible for progressive renal injury and end stage renal failure. Partial insight has been achieved in the role of a few molecules that represent snapshots in time of the complex, largely unknown regulatory pathways. In the concerted action on renal fibrosis and scarring (BMH4-CT98-3631) we have established a unique tissue bank of precious renal biopsies of patients with the most common causes of renal disease from expert centres of the European Union. It is the purpose of the present project to delineate the common molecular pathways of renal injury using state of the art genomics and protenomics approaches and design diagnostic tools to predict progression and prevent end stage renal failure.
Funding SchemeCSC - Cost-sharing contracts
65926 Frankfurt Am-main
AB25 2ZD Aberdeen