Objective
Monochorionic (MC) twins are rare (3/1,000) but have a much higher risk of perinatal death or neurological sequelae than dichorionic twins or singleton pregnancies. Furthermore, 15 % of MC twin gestations complicate with the Twin-to-twin transfusion syndrome (TTS). The cause for this poorer outcome lies in the ever-present vascular connections in the MC placentas. Although MC status can be identified early in pregnancy, this is often not done due to unawareness of its consequences. There are neither data to offer guidance on how to follow up these high-risk pregnancies, nor how to treat TTS. Clinical studies are proposed to improve pathophysiologic insight, such as the determination of the natural history of early-diagnosed MC twins and the exact risk for developing TTS. We will evaluate the incidence and nature of long-term sequelae in survivors of TTS. A prospective study will be conducted to determine which is the best therapy for TTS, neurological morbidity in survivors being the primary variable. In our study patients we will determine the placental angioarchitecture, correlate it to clinical pregnancy outcome and use this information to establish a computer model for the disease. In addition instrumental innovations are proposed to improve therapy of TTS and abnormal MC twin pregnancy.
Fields of science (EuroSciVoc)
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CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques.
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Call for proposal
Data not availableFunding Scheme
CSC - Cost-sharing contractsCoordinator
3000 LOUVAIN / LEUVEN
Belgium