Objective
The major goal of this proposal is to identify genes witch play an important role in pancreas development and to elaborate a model describing pancreas organogenesis. This will be achieved in four stages :
i) cloning of novel putative regulatory genes from pancreatic cells,
ii) analysis of the expression pattern of these novel genes
iii) determination of the function of the new genes
iv) study of the regulatory circuits existing between these factors. These tasks will be performed by taking advantage of three complementary biological models :
i)mammalian pancreatic cell lines,
ii) zebrafish and
iii) mouse. Also, we will determine whether differentiation of mouse embryonic stem cells into pancreatic beta cell type can be achieved through the controlled expression of key pancreatic factors identified during this project . This proposal is likely to have profound impacts for the development of new diagnostics tools or of new therapies for diabetes.
Fields of science (EuroSciVoc)
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques.
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques.
- medical and health sciencesclinical medicineendocrinologydiabetes
- medical and health sciencesmedical biotechnologycells technologiesstem cells
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Call for proposal
Data not availableFunding Scheme
CSC - Cost-sharing contractsCoordinator
4000 LIEGE
Belgium