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Fast interpretation of nmr data for structural and functional analysis of proteins

Objective

A tested and validated NMR toolkit for the fast determination of protein structures, in particular for proteins containing new folds, is developed in the project. The time needed to find a novel protein fold will be reduced by at least a factor of five over current procedures, by using automated techniques for the determination of secondary and tertiary structure and the integration of NMR, proteins expression and bio-informatics procedures. In the NMR structure determination NMR parameters depending on the partial alignment of the protein solute, i.e. residual dipolar coupling, chemical shift anisotropy and paramagnetic effects, and croscorrelation effects will be used to J-couplings and NOE's.

Funding Scheme

CSC - Cost-sharing contracts

Coordinator

WISE & MUNRO LEARNING RESEARCH
Address
8,Azaleastraat 85
2565 CD Den Haag
Netherlands

Participants (7)

AVENTIS RESEARCH & TECHNOLOGIES GMBH & CO KG
Germany
Address
Industriepark Höchst Gebäude K703
65926 Frankfurt Am Main
CONSORZIO INTERUNIVERSITARIO RISONANZE MAGNETICHE DI METALLOPROTEINE PARAMAGNETICHE
Italy
Address
Via Luigi Sacconi 6
Sesto Fiorentino
EUROPEAN MOLECULAR BIOLOGY LABORATORY
Germany
Address
Meyerhofstrasse 1
69012 Heidelberg
JOHANN WOLFGANG GOETHE UNIVERSITAET FRANKFURT
Germany
Address
Seckenberg Anlage 31
60054 Frankfurt Am-main
N.V. ORGANON
Netherlands
Address
Molenstraat 20
5340 BH Oss
SMITHKLINE BEECHAM PLC
United Kingdom
Address
New Horizons Court
TW8 9EP Brentford
University of East Anglia
United Kingdom
Address
University Plain
NR4 7TJ Norwich