Cel
A tested and validated NMR toolkit for the fast determination of protein structures, in particular for proteins containing new folds, is developed in the project. The time needed to find a novel protein fold will be reduced by at least a factor of five over current procedures, by using automated techniques for the determination of secondary and tertiary structure and the integration of NMR, proteins expression and bio-informatics procedures. In the NMR structure determination NMR parameters depending on the partial alignment of the protein solute, i.e. residual dipolar coupling, chemical shift anisotropy and paramagnetic effects, and croscorrelation effects will be used to J-couplings and NOE's.
Dziedzina nauki
Zaproszenie do składania wniosków
Data not availableSystem finansowania
CSC - Cost-sharing contractsKoordynator
2565 CD DEN HAAG
Niderlandy