Associomics of membrane proteins in two model organisms, yeast and arabidopsis (ASSOCIOPORT)

Objective

Associomics is central for functional analysis of proteomes with great promises for predicting protein functions. Membrane proteins (MPs) play important roles in physiological processes (transport, signalling, trafficking, cell adhesion). However, due to their intrinsic properties, MPs are not amenable to associomic analysis using standard methods. In ASSOCIOPORT, academic teams and SMEs will undertake large-scale screening to systematically identify MP interactions. For this, the split-ubiquity two-hybrid system will be developed as a high-throughput screening tool and applied to 1024 MPs in the models yeast and Arabidopsis. The project will provide invaluable information on membrane-associated processes. It represents a pilot study to analyse all interactions of human MPs. Results will be exploited to develop targets for new pharma- and agrochemicals, design assays for drug testing, and provide screens as services.

Fields of science

• natural sciences › biological sciences › biochemistry › biomolecules › proteins › proteomics
• natural sciences › biological sciences › cell biology
• natural sciences › mathematics › pure mathematics › mathematical analysis › functional analysis

Programme(s)

• FP5-LIFE QUALITY - Specific Programme for research, technological development and demonstration on "Quality of life and management of living resources", 1998-2002

Topic(s)

• 1.1.1.-8. - Research into genomes and diseases of genetic origin

Call for proposal

Data not available

Funding Scheme

CSC - Cost-sharing contracts

Coordinator

THE UNIVERSITY OF TUEBINGEN

Address

Auf Der Morgenstelle 1
72076 Tuebingen
Germany

Participants (6)

GENEXPRESS GESELLSCHAFT FUER PROTEINDESIGN MBH

Germany

Address

Tempelhofer Weg 11-12
10829 Berlin

HEINRICH-HEINE-UNIVERSITAET DUESSELDORF

Germany

Address

Universitätsstraße 1, 26.12
40225 Duesseldorf

OLFERT LANDT TIB MOLBIOL SYNTHESELABOR

Germany

Address

Tempelhofer Weg 11-12
10829 Berlin

SYMPORE GMBH

Germany

Address

Auf Der Morgenstelle 1
72076 Tuebingen

UNIVERSITE LIBRE DE BRUXELLES

Belgium

Address

Rue Des Pr. Jeener Et Brachet, 12
6041 Gosselies

UNIVERSITY OF SALAMANCA

Spain

Address

S/n,avenida Del Campo Charro S/n
37007 Salamanca