Associomics is central for functional analysis of proteomes with great promises for predicting protein functions. Membrane proteins (MPs) play important roles in physiological processes (transport, signalling, trafficking, cell adhesion). However, due to their intrinsic properties, MPs are not amenable to associomic analysis using standard methods. In ASSOCIOPORT, academic teams and SMEs will undertake large-scale screening to systematically identify MP interactions. For this, the split-ubiquity two-hybrid system will be developed as a high-throughput screening tool and applied to 1024 MPs in the models yeast and Arabidopsis. The project will provide invaluable information on membrane-associated processes. It represents a pilot study to analyse all interactions of human MPs. Results will be exploited to develop targets for new pharma- and agrochemicals, design assays for drug testing, and provide screens as services.
Funding SchemeCSC - Cost-sharing contracts