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Associomics of membrane proteins in two model organisms, yeast and arabidopsis (ASSOCIOPORT)

Objective

Associomics is central for functional analysis of proteomes with great promises for predicting protein functions. Membrane proteins (MPs) play important roles in physiological processes (transport, signalling, trafficking, cell adhesion). However, due to their intrinsic properties, MPs are not amenable to associomic analysis using standard methods. In ASSOCIOPORT, academic teams and SMEs will undertake large-scale screening to systematically identify MP interactions. For this, the split-ubiquity two-hybrid system will be developed as a high-throughput screening tool and applied to 1024 MPs in the models yeast and Arabidopsis. The project will provide invaluable information on membrane-associated processes. It represents a pilot study to analyse all interactions of human MPs. Results will be exploited to develop targets for new pharma- and agrochemicals, design assays for drug testing, and provide screens as services.

Funding Scheme

CSC - Cost-sharing contracts

Coordinator

THE UNIVERSITY OF TUEBINGEN
Address
Auf Der Morgenstelle 1
72076 Tuebingen
Germany

Participants (6)

GENEXPRESS GESELLSCHAFT FUER PROTEINDESIGN MBH
Germany
Address
Tempelhofer Weg 11-12
10829 Berlin
HEINRICH-HEINE-UNIVERSITAET DUESSELDORF
Germany
Address
Universitätsstraße 1, 26.12
40225 Duesseldorf
OLFERT LANDT TIB MOLBIOL SYNTHESELABOR
Germany
Address
Tempelhofer Weg 11-12
10829 Berlin
SYMPORE GMBH
Germany
Address
Auf Der Morgenstelle 1
72076 Tuebingen
UNIVERSITE LIBRE DE BRUXELLES
Belgium
Address
Rue Des Pr. Jeener Et Brachet, 12
6041 Gosselies
UNIVERSITY OF SALAMANCA
Spain
Address
S/n,avenida Del Campo Charro S/n
37007 Salamanca