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Understanding human molecular physiology and pathology through integrated functional genomics in the mouse model

Objective

An integrated approach applying phenotyping, mutagenesis, informatics to development of mouse models/understanding of human physiology/disease, focusing on the development/standardisation of primary and secondary phenotyping protocols for all body systems in the mouse underpinned by substantial networking involving working groups from EU and abroad bringing expertise to bear in the development/validation of screens We will pilot novel approaches to gene-driven mutagenesis. The programme is supported by new informatics developments within research/networking focusing on provision of tools for dissemination, acquisition and querying of phenotype data. The training programme bolsters research bringing new skills from diverse areas e.g. veterinary and clinical medicine to mouse biology and the study of disease models, while also creating a new cadre of scientists trained in mouse genetics. EUMORPHIA prepares the EU community for future challenges re Genomes for Human Health.

Funding Scheme

CSC - Cost-sharing contracts

Coordinator

MEDICAL RESEARCH COUNCIL
Address
Harwell
OX11 0RD Didcot,harwell,chilton
United Kingdom

Participants (17)

CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE
France
Address
Rue De La Ferollerie 3B
45071 Orleans
CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE
France
Address
Boulevard Pinel, 59
69003 Lyon
CENTRO NACIONAL DE INVESTIGATIONES ONCOLOGICAS
Spain
Address
C/ Melchor Fernandes Almagro, 3
28029 Madrid
CONSORTIUM NATIONAL DE RECHERCHE EN GNOMIQUE
France
Address
Rue Gaston Cremieux, 2
91057 Evry
EUROPEAN MOLECULAR BIOLOGY LABORATORY
Italy
Address
Via E. Ramarini 32
00016 Monterotondo
GBF - NATIONAL CENTRE FOR BIOTECHNOLOGY
Germany
Address
Mascheroder Weg 1
38124 Braunschweig
GENOME RESEARCH LTD.
United Kingdom
Address
The Wellcome Trust Genome Campus Hinxton
CB10 1SA Saffron Walden
GROUPEMENT D'INTERET ECONOMIQUE - CENTRE EUROPEEN DE RECHERCHE EN BIOLOGIE ET MEDECINE
France
Address
Rue Laurent Fries, 1 - Igbmc
674044 Illkirch Graffenstaden
GSF-RESEARCH CENTER FOR ENVIRONMENT AND HEALTH
Germany
Address
Ingolstaedter Landstrasse 1
85764 Neuherberg
INSTITUT NATIONAL DES SCIENCES APPLIQUEES DE LYON
France
Address
Boulevard Pinel, 59
69003 Lyon
KAROLINSKA INSTITUTE
Sweden
Address
Von Eulers Vag 3
171 77 Stockholm
NATIONAL RESEARCH COUNCIL OF ITALY
Italy
Address
Via E.ramarini 32
00016 Monterotondo
THE NETHERLANDS CANCER INSTITUTE / ANTONI VAN LEEUWENHOEK HOSPITAL
Netherlands
Address
121,Plesmanlaan 121
1066 CX Amsterdam
UNIVERSITE CLAUDE BERNARD LYON 1
France
Address
Boulevard Pinel, 59
69003 Lyon
UNIVERSITY OF GENEVA
Switzerland
Address
Quai Ernest-ansermet 30
1211 Geneve
UNIVERSITY OF LAUSANE
Switzerland
Address
Batiment De Biologie
1015 Lausanne
UNIVERSITY OF MANCHESTER
United Kingdom
Address
Oxford Road
M13 9WL Manchester