Skip to main content

Towards a unified theory of protein structural fragments and their application for protein engineering and misfolding related diseases (protein folding fragments)

Objective

Due to the systematic sequencing projects, the gap between the number of available protein sequences and structures increases, and the need for developing global proteomic programs becomes crucial. In this context, the prediction of new folds from scratch and the identification of characteristic folding fragments are necessary steps towards rational protein engineering and the elucidation of diseases related to misfolded structures. All the groups involved develop in silicon methods for determining protein structural subunits likely to correspond to key elements in the folding process. Our objective is to combine the expertise of the different groups and to transfer ideas and results in view of improving the efficiency of the individual approaches and establishing a synergetic prediction scheme of protein structure from sequence and conversely.

Funding Scheme

CON - Coordination of research actions

Coordinator

UNIVERSITE PIERRE ET MARIE CURIE - PARIS VI
Address
Place Jussieu, 4
75252 Paris
France

Participants (7)

AGRICULTURAL UNIVERSITY OF ATHENS
Greece
Address
Iera Odos 75
11855 Athens
CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE
France
Address
Bat.430 Universite Paris Sud 11
91405 Orsay
EUROPEAN MOLECULAR BIOLOGY LABORATORY
Germany
Address
Meyerhofstrasse 1
102209 Heidelberg
UNIVERSITE DE PARIS-SUD XI
France
Address
Bat.430 Université Paris Sud 11
91405 Orsay
UNIVERSITE LIBRE DE BRUXELLES
Belgium
Address
Avenue Franklin Roosevelt 50
1050 Bruxelles
UNIVERSITY OF HAIFA
Israel
Address
Mont Carmel
31905 Haifa
UNIVERSITY OF MANCHESTER
United Kingdom
Address
Oxford Road
Manchester