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Neural stem cells and stem cell-based therapies

Objective

Therapies aimed at restoring neurological function by intracerebraltransplantation brings about ethical issues relative to the use of embryonic or foetal tissues. Human stem cells may represent a substitute for the use of such tissues In any grafting therapy. However, in order to use these cells successfully, it is necessary to fully understand the basic mechanisms that regulate there proliferate state, their mode of division and their differentiation potentials. Two major avenues will be pursued:
i) In vivo and inviter analysis of neural stem cell behaviour in simple organisms such asDrosophila melanogaster as well as in vertebrate nervous system;
ii) Design of cell replacement protocols in animal model systems for post-traumatic disorder.

Funding Scheme

CSC - Cost-sharing contracts

Coordinator

CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE
Address
Rue Laurent Fries 1
67404 Illkirch Graffenstaden
France

Participants (5)

FONDAZIONE CENTRO SAN RAFFAELE DEL MONTE TABOR - ISTITUTO DI RICOVERO E CURA A CARATTERE SCIENTIFICO
Italy
Address
Via Olgettina 58
20132 Milano
JOHANNES GUTENBERG UNIVERSITAET MAINZ
Germany
Address
Joh.-joachim-becher-weg 32
55128 Mainz
KING'S COLLEGE LONDON
United Kingdom
Address
De Crespigny Park
W8 7AH London
UNIVERSITY COLLEGE LONDON
United Kingdom
Address
The Cruciform Building, Gower Street
WC1E 6BT London
UNIVERSITY OF UMEAA
Sweden
Address
Universitetsomraadet
901 87 Umeaa