Therapies aimed at restoring neurological function by intracerebraltransplantation brings about ethical issues relative to the use of embryonic or foetal tissues. Human stem cells may represent a substitute for the use of such tissues In any grafting therapy. However, in order to use these cells successfully, it is necessary to fully understand the basic mechanisms that regulate there proliferate state, their mode of division and their differentiation potentials. Two major avenues will be pursued:
i) In vivo and inviter analysis of neural stem cell behaviour in simple organisms such asDrosophila melanogaster as well as in vertebrate nervous system;
ii) Design of cell replacement protocols in animal model systems for post-traumatic disorder.
Funding SchemeCSC - Cost-sharing contracts
W8 7AH London
WC1E 6BT London
901 87 Umeaa