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The bionic ear, a new approch to trigger repair mechanisms in the inner ear

Objective

This project aims at designing a new therapeutic approach for the restoration of sensory function after damage in the inner ear auditory and balance organs. This goal will be reached through the better understanding of the regenerative and "neo-synaptogenesis" potential of inner ear sensory neurons and on how this potential can be enhanced in vivo in hearing impaired animals. Stem cell lines from normal animals and form transgenic animals over expressing neurotrophic factors will be established and these cells will be further manipulated using genetic engineering. The ability of these cells to support regeneration in the inner ear will be assessed with functional in vitro and in vivo approaches. This cell therapy approach will be combined with existing biopolymer implants and with existing cochlear electrode prosthesis into a BIOELECTRODE implant.

Funding Scheme

CSC - Cost-sharing contracts

Coordinator

CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE
Address
Avenue Du Fontaule 1
66651 Banyuls Sur Mer
France

Participants (3)

KAROLINSKA INSTITUTE
Sweden
Address
Novum, Kfc Plan 4
141 86 Stockholm
NATIONAL RESEARCH COUNCIL OF ITALY
Italy
Address
Via Vanvitelli 32
20129 Milano
SWISS FEDERAL INSTITUTE OF TECHNOLOGY LAUSANNE
Switzerland
Address
Aab 132
1015 Lausanne