Objective Primary regional organisation of the vertebrate brain is specified by gene cascades, which reactivated during early embryogenesis. Identities of different brain regions are partly defined by gene families having similar functions in Drosophilae and vertebrates, indicating regulatory mechanisms that are strongly conserved in evolution. Despite fragmentary knowledge about different aspects of early neural development, there is not yet an integrated picture of the regulatory cascades which set-up the primary organisation of the brain. This is a central unsolved problem in the neurosciences. The proposed programme coordinates the complementary expertises of six specialist groups to elucidate mechanisms underlying development of different brain regions and determine how their construction is coordinated. We expect that these investigations will provide a solid basis for understanding how the brain is built and how its organisation is disturbed by genetic disease. Fields of science natural sciencesbiological sciencesneurobiologynatural sciencesbiological sciencesdevelopmental biology Programme(s) FP5-LIFE QUALITY - Specific Programme for research, technological development and demonstration on "Quality of life and management of living resources", 1998-2002 Topic(s) 1.1.1.-9. - Neurosciences Call for proposal Data not available Funding Scheme CSC - Cost-sharing contracts Coordinator NETHERLANDS INSTITUTE FOR DEVELOPMENTAL BIOLOGY EU contribution No data Address 8,Uppsalalaan 8 3584 CT UTRECHT Netherlands See on map Total cost No data Participants (5) Sort alphabetically Sort by EU Contribution Expand all Collapse all INSTITUT PASTEUR France EU contribution No data Address 25,Rue du Docteur Roux 28 75724 PARIS See on map Total cost No data MAX-PLANCK-GESELLSCHAFT ZUR FOERDERUNG DER WISSENSCHAFTEN E.V. Germany EU contribution No data Address 11,Am Fassberg 11 37077 Göttingen - Nikolausberg See on map Total cost No data MRC National Institute for Medical Research United Kingdom EU contribution No data Address The Ridgeway Mill Hil NW7 1AA London See on map Total cost No data UNIVERSIDAD MIGUEL HERNANDEZ DE ELCHE Spain EU contribution No data Address Campus de San Juan - Ctra Alicante-Valencia Km 8,7 03550 SAN JUAN DE ALICANTE See on map Total cost No data UNIVERSITA VITA-SALUTE SAN RAFFAELE Italy EU contribution No data Address Via Olgettina 58 20132 MILANO See on map Total cost No data
