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The genetic control of brain development

Objective

Primary regional organisation of the vertebrate brain is specified by gene cascades, which reactivated during early embryogenesis. Identities of different brain regions are partly defined by gene families having similar functions in Drosophilae and vertebrates, indicating regulatory mechanisms that are strongly conserved in evolution. Despite fragmentary knowledge about different aspects of early neural development, there is not yet an integrated picture of the regulatory cascades which set-up the primary organisation of the brain. This is a central unsolved problem in the neurosciences. The proposed programme coordinates the complementary expertises of six specialist groups to elucidate mechanisms underlying development of different brain regions and determine how their construction is coordinated. We expect that these investigations will provide a solid basis for understanding how the brain is built and how its organisation is disturbed by genetic disease.

Funding Scheme

CSC - Cost-sharing contracts

Coordinator

NETHERLANDS INSTITUTE FOR DEVELOPMENTAL BIOLOGY
Address
8,Uppsalalaan 8
3584 CT Utrecht
Netherlands

Participants (5)

INSTITUT PASTEUR
France
Address
25,Rue Du Docteur Roux 28
75724 Paris
MAX-PLANCK-GESELLSCHAFT ZUR FOERDERUNG DER WISSENSCHAFTEN E.V.
Germany
Address
11,Am Fassberg 11
37077 Göttingen - Nikolausberg
MRC National Institute for Medical Research
United Kingdom
Address
The Ridgeway Mill Hil
NW7 1AA London
UNIVERSIDAD MIGUEL HERNANDEZ DE ELCHE
Spain
Address
Campus De San Juan - Ctra Alicante-valencia Km 8,7
03550 San Juan De Alicante
UNIVERSITA VITA-SALUTE SAN RAFFAELE
Italy
Address
Via Olgettina 58
20132 Milano