Objective
We aim to determine the 3D structure of the prototypic neurotransmitter receptor, the nicotinic acetylcholinereceptor (Ache), at high resolution, for understanding the structural basis of its function, using advanced electron and X-ray crystallography, NMR, AFM, molecular modelling and electro physiology, combined with antibody and legend labelling. The best available image of a neurotransmitter receptor is that of the Ache at 4.6AA resolution, obtained by partner 2. Our objectives are to achieve:
a. high resolution structure of closed and open Ache channels by electron microscopy;
b. imaging individual Aches in action by AFM;
c. X-ray structure of Ache channels;
d. conformation (by NMR and X-ray crystallography) of Ache fragments;
e. characterization of legend and protein binding properties;
f. detailed models of Torpedo and human Aches byte combined results, rational design of subtype-specific legends and legend assessment by electro physiology. Elucidation of the structure-function relationship of Aches will be catalytic to numerous studies in synapse function and dysfunction.
Fields of science (EuroSciVoc)
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
- natural sciences earth and related environmental sciences geology mineralogy crystallography
- natural sciences biological sciences biochemistry biomolecules proteins
- natural sciences physical sciences optics microscopy electron microscopy
- medical and health sciences basic medicine physiology
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Programme(s)
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Topic(s)
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Call for proposal
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Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
Funding Scheme
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Coordinator
11521 ATHENS
Greece
The total costs incurred by this organisation to participate in the project, including direct and indirect costs. This amount is a subset of the overall project budget.