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Molecular, cellular and genetic interactions in vertebrate eye development (EYE DEVELOPMENT)

Objective

A molecular explanation of how the vertebrate eye is built is the goal of this proposal. This is broken into three stages, the formation of the eye anlagen, the subdivision of the optic vesicle into the retina, pigment epithelium, and optics talk, and the generation of various neuronal cell types in the retina. The experiments here take advantage of modern molecular genetic analysis in four powerful vertebrate species to elucidate the roles the key genes involved in these processes and to identify new genes. Much of the work is focused on understanding the genetic and cellular interactions, the interplay of signalling molecules and transcription factors, extrinsic and intrinsic components of the genetic network of eye development. The recent discovery of retinal stem cells in vertebrates stimulates the last part of this proposal, a detailed characterisation of these cells using the knowledge gained from the investigation into eye development.

Coordinator

University of Cambridge
Address
Downing Street
CB2 3DY Cambridge
United Kingdom

Participants (6)

CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE
France
Address
Bètiment 445 - Université De Paris-sud
91405 Orsay
CONSEJO SUPERIOR DE INVESTIGACIONES CIENTIFICAS
Spain
Address
Av. Doctor Arce 37
28002 Madrid
EUROPEAN MOLECULAR BIOLOGY LABORATORY
Germany
Address
Meyerhofstrasse 1
69012 Heidelberg
UNIVERSITA DEGLI STUDI DI PISA
Italy
Address
Via G. Carducci 13
56010 Ghezzano
UNIVERSITE DE PARIS-SUD XI
France
Address

91405 Gometz La Ville
UNIVERSITY COLLEGE LONDON
United Kingdom
Address
Gower Street
London