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Comparative approach to the analysis of molecular pathways underlying cell communication mechanisms in forebrain patterning (FOREBRAIN PATTERNING)

Objective

We propose an integrated approach to study the molecular basis of cell communication processes generating neural diversity in forebrain development in chick, mouse and zebra fish embryos. Our ultimate goal is to understand the signals that define the variety of neural cell types in the forebrain. We will focus on understanding the zone limiting intrathalamica (sly), an important signalling centre recently discovered in the forebrain. A combination of experimental embryology and molecular techniques exploiting the different strengths of each model organism will be used to study the development, signalling activity and interactions of the sly. Isolation and functional studies of key genes will determine the role of these genes in the sly, and in forebrain development more generally. This understanding will form an essential basis for designing repair strategies for the damaged or deceased human brain.

Funding Scheme

CSC - Cost-sharing contracts

Coordinator

N/A

Participants (3)

KING'S COLLEGE LONDON
United Kingdom
Address
London Bridge, New Hunt's House, Guy's Campus
SE1 1UL London
UNIVERSIDAD MIGUEL HERNANDEZ DE ELCHE
Spain
Address
Campus De San Juan - Ctra Alicante-valencia Km 8,7
03550 San Juan De Alicante
UNIVERSITY OF CATANIA
Italy
Address
Viale A. Doria 6, Cittadella Universitaria
95125 Catania