Objective
In addition to the classical, polarised release of neurotransmitter that takes place at synapses, neurones communicate with each other through another, and less well understood mechanism called retrograde inhibition. Here neurones emit a messenger molecule from their somatodendritic membrane when they fire action potentials, and this molecule induces an inhibitory signal in the axon and synaptic terminals ofpresynaptic neurones. The aim of this proposal is to test whether retrograde inhibition results from the exocytotic release of classical neurotransmitters from the somatodendritic domain of the releasing neuron, and to compare this type ofexocytosis with that taking place at axon terminals. The participation of novelexocytotic proteins, which are insensitive to clostridia neurotoxins, will be investigated. Methods will include molecular biology, immunohistochemistry, electron microscopy, patch-clamp recording and amperommetry.
Fields of science (EuroSciVoc)
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
- natural sciences biological sciences neurobiology
- natural sciences biological sciences biochemistry biomolecules proteins
- natural sciences physical sciences optics microscopy electron microscopy
- natural sciences biological sciences molecular biology
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Programme(s)
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Topic(s)
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Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
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Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
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Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Coordinator
75270 PARIS
France
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