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A bio-active cochlear implant for severe deafness

Objective

A cochlear implant (CI) is a neuro-prosthesis for severe deafness. Our main objective is to pharmacologically treat the auditory nerve after CI, to protect the nerve from implantation trauma and to re-grow its peripheral processes. This treatment should improve speech understanding, enhancing the life quality of the patient. Animal studies, and studies on human tissue samples, will be performed to determine the efficacy of neurotrophins and antioxidants in preserving the auditory nerve following deafness. Delivery systems will also designed to supply drugs at the time of CI. Safety, effectiveness and dosage will be investigated, leading eventually to the first human trials of NTF in the inner ear. The outcomes of the research will have implications for the pharmacological treatment of hearing loss, for the use of NTF to prevent neural degeneration in CNS and for other neuroprostheses.

Funding Scheme

CSC - Cost-sharing contracts

Coordinator

UNIVERSITY OF TAMPERE
Address
4,Medisiinarinkatu 3
33014 Tampere
Finland

Participants (8)

BCI BIOABSORBABLE CONCEPTS OY
Finland
Address
Hermiankatu 6-8 L
33720 Tampere
HANNOVER MEDICAL SCHOOL
Germany
Address
Carl-neuberg-strasse 1
30625 Hannover
KAROLINSKA INSTITUTE
Sweden
Address
12,Berzelius Vaeg 3
171 77 Stockholm
LEOPOLD-FRANZENS-UNIVERSITAET INNSBRUCK
Austria
Address
Anichstrasse, 35
6020 Innsbruck
MED-EL GMBH
Austria
Address
Fuerstenweg 77A
6020 Innsbruck
TAMPERE UNIVERSITY OF TECHNOLOGY
Finland
Address
Korkeakoulunkatu 6
33101 Tampere
UNIVERSIT DEGLI STUDI DI FERRARA
Italy
Address
Corso Della Giovecca 203
44100 Ferrara
UPPSALA UNIVERSITY
Sweden
Address
St Olofsgatan, 10 B
75185 Uppsala