Objective Human adaptation to modern 24-h society is constrained by dominant endogenous periodicities in physiology and behaviour. These rhythms, including the sleep-wake cycle, are generated in the brain's suprachiasmatic nuclei (SCN). Their understanding has major biomedical impact in the combat of sleep disorders, control of fatigue and risk, adjustment to shift work, timing of drug therapies. Big strides are being made in unravelling the physiological and molecular basis of circadian rhythms. Building on these advances we combine molecular, brain and behaviour studies to elucidate the control of sleep-wakefulness in mouse models and humans. Human studies focus on screening for phase variations in sleep-wake rhythms and their molecular characterization. Mouse strains with genetically modified circadian genes are exploited to characterize the mechanism underlying SCN oscillations and establish time-specific neuroanatomical mapping of circadian gene expression throughout the brain. Complementary expertise allows the assembly of a coherent picture of generation and synchronization of neuronal clocks involved in adaptation to a rotating planet. Fields of science medical and health sciencesclinical medicinepsychiatrysleep disorderssocial sciencespsychologybehavioural psychologynatural sciencesphysical sciencesastronomyplanetary sciencesplanetsmedical and health sciencesbasic medicinephysiology Programme(s) FP5-LIFE QUALITY - Specific Programme for research, technological development and demonstration on "Quality of life and management of living resources", 1998-2002 Topic(s) 1.1.1.-9. - Neurosciences Call for proposal Data not available Funding Scheme CSC - Cost-sharing contracts Coordinator N/A Address See on map EU contribution € 0,00 Participants (4) Sort alphabetically Sort by EU Contribution Expand all Collapse all ERASMUS UNIVERSITEIT ROTTERDAM Netherlands EU contribution € 0,00 Address Dr. molewaterplein 50 3000 DR Rotterdam See on map LUDWIG-MAXIMILIANS UNIVERSITY OF MUNICH Germany EU contribution € 0,00 Address Goethestrasse 31 80336 Muenchen See on map MAX-PLANCK-GESELLSCHAFT ZUR FOERDERUNG DER WISSENSCHAFTEN E.V. Germany EU contribution € 0,00 Address Feodor-lynen-dtrasse 7 30603 Hannover See on map UNIVERSITY OF FRIBOURG Switzerland EU contribution € 0,00 Address Rue du musee 5 1700 Fribourg See on map
