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Identification and characterization of factors involved in cyp3a4 inter-individual variability

Objective

Cytochrome P450 3A4 bio transforms many xenobiotics in human liver and has a highly variable expression. Identification of the genetic factors underling this variability is a key step in the prevention of fatal adverse drug reactions and carcinogen sis.

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Coordinator

KAROLINSKA INSTITUTE
Address
Nobels Vaeg, 13
171 77 Stockholm
Sweden

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