Our proposal intends to broaden our knowledge of the molecular mechanisms, which govern normal cell physiology and are also important for the development of cancer within the immune-and haematopoietic systems. We have defined several areas of interest, including basic mechanisms of cell differentiation/proliferation (intracellular signalling, cell death and cell cycle regulation) as well as processes particular to the lymphoid cell lineages (recombination of their genetic material). To specifically address the multidisciplinary approach that is necessary to tackle the cancer problem, we have brought together 10 experts in the molecular biology of signal transudation, cell cycle, cell death and cellular differentiation as well as genetic recombination in order to better understand the origin and path physiology of leukaemia and lymphoma. Our work will focus on the basic understanding of molecular mechanisms to build upon our knowledge, which will lay down the foundation for the identification of targets for future therapy.
Funding SchemeCSC - Cost-sharing contracts
CB1 7BZ Cambridge
CB2 1TN Cambridge
3584 CX Utrecht