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Strategies centered on the understanding of origin, pathophysiology and future treatment of cancer in the immune haematopoetic system

Objective

Our proposal intends to broaden our knowledge of the molecular mechanisms, which govern normal cell physiology and are also important for the development of cancer within the immune-and haematopoietic systems. We have defined several areas of interest, including basic mechanisms of cell differentiation/proliferation (intracellular signalling, cell death and cell cycle regulation) as well as processes particular to the lymphoid cell lineages (recombination of their genetic material). To specifically address the multidisciplinary approach that is necessary to tackle the cancer problem, we have brought together 10 experts in the molecular biology of signal transudation, cell cycle, cell death and cellular differentiation as well as genetic recombination in order to better understand the origin and path physiology of leukaemia and lymphoma. Our work will focus on the basic understanding of molecular mechanisms to build upon our knowledge, which will lay down the foundation for the identification of targets for future therapy.

Funding Scheme

CSC - Cost-sharing contracts

Coordinator

UNIVERSITY OF TURKU
Address
Kiinamyllynkatu 13
20014 Turku
Finland

Participants (9)

CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE
France
Address
Parc Scientifique Et Technologique De Luminy
13288 Marseille
INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE
France
Address
Parc Scientifique De Luminy
13288 Marseille
JOHANNES GUTENBERG UNIVERSITAET MAINZ
Germany
Address
Obere Zahlbacher Straße 67
55131 Mainz
PARADIGM THERAPEUTICS LIMITED
United Kingdom
Address
Coniston Road 11
CB1 7BZ Cambridge
THE CHANCELLOR, MASTERS AND SCHOLARS OF THE UNIVERSITY OF CAMBRIDGE
United Kingdom
Address
Trinity Lane, The Old Schools,
CB2 1TN Cambridge
THE HEBREW UNIVERSITY OF JERUSALEM - THE AUTHORITY FOR RESEARCH AND DEVELOPMENT
Israel
Address
Givat Ram Campus, Edmond Safra
91904 Jerusalem
UNIVERSITAETSKLINIKUM HEIDELBERG
Germany
Address
Vossstrasse 2
69115 Heidelberg
UNIVERSITY HOSPITAL UTRECHT
Netherlands
Address
100,Heidelberglaan 100
3584 CX Utrecht
University of Nottingham
United Kingdom
Address
University Park
NG7 2RD Nottingham