The Role Tissue Transglutaminase in Inducing Gluten T Cell Response and Autoantibody Formation in Coeliac Disease

Objective

Deamidation and transamidation activities of tTG are measured and the influence of tTG autoantibodies is determined. Gluten-tTG complexes are applied to investigate the role of cognate T/B cell interaction for the formation of tTG autoantibodies. An in vitro murine system, a murine adoptive transfer model and an in vitro human system will be used.

Programme(s)

• FP5-LIFE QUALITY - Specific Programme for research, technological development and demonstration on "Quality of life and management of living resources", 1998-2002

Funding Scheme

RGI - Research grants (individual fellowships)

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Coordinator

University of Oslo

Address

Rikshospitalet
0027 Oslo
Norway

Participants (1)

Not available

Germany