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Bound residues and nitrofuran detection

Objective

The use of nitrofuran antibiotics in farm animals was banned in the EU because of their toxicity. Monitoring compliance with the ban by testing for residues of the parent drugs is ineffective, because they are rapidly metabolised in vivo, and their residues are unstable. Nitrofuran metabolism is complex, with extensive formation of stable, tissue-bound residues with relatively long tissue half lives. Mild acids (like the human stomach) release potentially toxic compounds from bound nitrofuran residues. This project will develop screening tests and a Reference Method for these compounds, to provide an effective tool f or surveillance and enforcement. Methods will be extensively validated according to current EU guidelines; will be used to measure the prevalence of the bound residues in a pan-European survey and to define the length of time for which illegal abuse can be detected. A project web site, a Consumer Awareness Forum, National Reference Laboratory Technology Transfer events and articles prepared for the consumer press will ensure maximum dissemination of the aims and findings of the work to end users; and an SME will develop novel, marketable products.

Funding Scheme

CSC - Cost-sharing contracts

Coordinator

THE QUEEN'S UNIVERSITY OF BELFAST
Address
Stoney Road , Stormont
BT4 3SD Belfast
United Kingdom

Participants (5)

ASSOCIATION DES CONSOMMATEURS TEST- ACHATS
Belgium
Address
Hollandstraat 13
1060 Bruxelles
NATIONAL FOOD INVESTIGATION INSTITUTE
Hungary
Address
Mester Utca 81
1465 Budapest
R- BIOPHARM GMBH
Germany
Address
Dolivostrasse 10
64293 Darmstadt
TEAGASC - AGRICULTURE AND FOOD DEVELOPMENT AUTHORITY
Ireland
Address
19,Dunsinea, Castleknock
15 Dublin
VETERINARY RESEARCH INSTITUTE
Czechia
Address
70,Hudcova 70
621 32 Brno