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Functional food ingredients against colorectal cancer - development of a genomics and proteomics based screening assay

Objective

More than half of the gastrointestinal tract cancers may be related to the diet. Research to identify active components in the diet reducing the cancer risk, to understand the mechanism of cancer prevention and (the last few years) to design functional foods with the specific goal to reduce the incidence of cancers has made considerable progress. However, a systematic search for effective (combinations of) food compounds or ingredients has not been performed, primarily due to lack of good methodology. An (in vitro) bioassay will be developed, based on genomic and proteomic changes in colorectal cells, to assess the efficacy of (functional) food ingredients in prevention or inhibition of the development of early stages of colorectal cancer. The genomic and proteomic changes in colorectal cells will be powerful biomarkers of colon carcinogenesis as a large portfolio of genes and proteins are tested simultaneously and the assays are easy to perform.

Funding Scheme

CSC - Cost-sharing contracts

Coordinator

NETHERLANDS ORGANISATION FOR APPLIED SCIENTIFIC RESEARCH - TNO
Address
48,Utrechtseweg 48
3700 AJ Zeist
Netherlands

Participants (4)

NONLINEAR DYNAMICS LIMITED
United Kingdom
Address
Tyne House Side 26
NE1 3JA Newcastle Upon Tyne
NUMICO RESEARCH B.V.
Netherlands
Address
Bosrandweg 20
6700 CA Wageningen
PALM MIKROLASER TECHNOLOGIE GMBH
Germany
Address
Am Neuland 9
82347 Bernried
ROSKILDE UNIVERSITY
Denmark
Address
35,Universitetsvej 1
4000 Roskilde