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Case-only study on the interaction of diet and genetic predisposition in the occurrence of breast cancer in young women.

Objective

The breast cancer (BC) risk of women with germ line mutations of Becalm or 2 or other high entrance genes is dramatically increased especially at young ages .Dietary and other modifiable life-style factors, however, may influence the early occurrence of BC in mutation carriers. Fruit and vegetable, vitamin E , say products and low glycaemia index food, as well as a low index of abdominal obesity , have been suggested to confer greater protection against hereditary Bethany against sporadic BC. Mechanistic explanations include hormonal effects of diet and antioxidant protection in women with impaired DNA repair. This CASE-ONLYSTUDY aims at testing exposure in patients with and without genetic predisposition, as established through family history or genetic testing. The study base will comprise over 5, 000 patients who got BC before the age of 40 .

Coordinator

ISTITUTO NAZIONALE PER LO STUDIO E LA CURA DEI TUMORI
Address
Via Venezian 1
20133 Milano
Italy

Participants (8)

CHAIM SHEBA MEDICAL CENTER
Israel
Address
Chair Sheba Medical Center
52621 Tel Hashomer
ESTONIAN INSTITUTE OF EXPERIMENTAL AND CLINICAL MEDICINE
Estonia
Address
Hiiu 42
0016 Tallinn
GERMAN CANCER RESEARCH CENTER
Germany
Address
Im Neuenheimer Feld 280
69120 Heidelberg
INSTITUTE OF ONCOLOGY LJUBLJANA
Slovenia
Address
Zaloska 2
1000 Ljubljana
LEGA ITALIANA PER LA LOTTA CONTRO I TUMORI - ONLUS
Italy
Address
Via Dante 109
97100 Ragusa
UNIVERSITE LOUIS PASTEUR, STRASBOURG 1
France
Address
Rue Kirschleger 4
67085 Strasbourg
UNIVERSITY OF ABERDEEN
United Kingdom
Address
Polwarth Building, Foresterhill
AB25 2ZD Aberdeen
UNIVERSITY OF ST ANDREWS
United Kingdom
Address
Queen's Terrace, Bute Medical Buildings
KY16 9TS St Andrews