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Case-only study on the interaction of diet and genetic predisposition in the occurrence of breast cancer in young women.

Cel

The breast cancer (BC) risk of women with germ line mutations of Becalm or 2 or other high entrance genes is dramatically increased especially at young ages .Dietary and other modifiable life-style factors, however, may influence the early occurrence of BC in mutation carriers. Fruit and vegetable, vitamin E , say products and low glycaemia index food, as well as a low index of abdominal obesity , have been suggested to confer greater protection against hereditary Bethany against sporadic BC. Mechanistic explanations include hormonal effects of diet and antioxidant protection in women with impaired DNA repair. This CASE-ONLYSTUDY aims at testing exposure in patients with and without genetic predisposition, as established through family history or genetic testing. The study base will comprise over 5, 000 patients who got BC before the age of 40 .

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Koordynator

ISTITUTO NAZIONALE PER LO STUDIO E LA CURA DEI TUMORI
Adres
Via Venezian 1
20133 Milano
Włochy

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Uczestnicy (8)

CHAIM SHEBA MEDICAL CENTER
Izrael
Adres
Chair Sheba Medical Center
52621 Tel Hashomer

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ESTONIAN INSTITUTE OF EXPERIMENTAL AND CLINICAL MEDICINE
Estonia
Adres
Hiiu 42
0016 Tallinn

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GERMAN CANCER RESEARCH CENTER
Niemcy
Adres
Im Neuenheimer Feld 280
69120 Heidelberg

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INSTITUTE OF ONCOLOGY LJUBLJANA
Słowenia
Adres
Zaloska 2
1000 Ljubljana

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LEGA ITALIANA PER LA LOTTA CONTRO I TUMORI - ONLUS
Włochy
Adres
Via Dante 109
97100 Ragusa

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UNIVERSITE LOUIS PASTEUR, STRASBOURG 1
Francja
Adres
Rue Kirschleger 4
67085 Strasbourg

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UNIVERSITY OF ABERDEEN
United Kingdom
Adres
Polwarth Building, Foresterhill
AB25 2ZD Aberdeen

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UNIVERSITY OF ST ANDREWS
United Kingdom
Adres
Queen's Terrace, Bute Medical Buildings
KY16 9TS St Andrews

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