The role of lipids in neurodegeneration and their preventive potential in diet

Objective

To prevent and treat age associated neurodegenerative diseases is a key challenge of this century. Based on recent findings it is promising to develop dietary lipid related disease prevention strategies. The present project will undertakethis strategic approach which will first be applied to Alzheimer's disease, in which brain lipids are believed to play an important role. Three converging lines of investigation will be pursued. In vitro studies of the role of lipids in neuronal degeneration and of the effects thereon of distinct lipid related treatments would be preformed first. The resulting promising treatments will than be used for the preparation of formulations whose effectiveness will be tested in vivo utilizing distinct models of neurodegeneration and dementia. The best diets will be tested in man for their ability to halt and prevent disease.

Programme(s)

• FP5-LIFE QUALITY - Specific Programme for research, technological development and demonstration on "Quality of life and management of living resources", 1998-2002

Topic(s)

• 1.1.1.-1. - Key action Food, Nutrition and Health

Funding Scheme

CSC - Cost-sharing contracts

Coordinator

RUPRECHT-KARLS-UNIVERSITAET HEIDELBERG

Address

Im Neuenheimer Feld 282
69120 Heidelberg
Germany

Participants (6)

INSTITUTE OF PHYSIOLOGY - CZECH ACADEMY OF SCIENCES

Czechia

Address

Videnska 1083
142 20 Praha 4

NUMICO RESEARCH B.V.

Netherlands

Address

Bosrandweg 20
6700 CA Wageningen

TEL AVIV UNIVERSITY

Israel

Address

Ramat-aviv
69978 Ramat - Aviv

UNIVERSITY OF GENEVA

Switzerland

Address

Rue Micherl Servet 1
1211 Geneve

UNIVERSITY OF KUOPIO

Finland

Address

9,Savilahdentie 9 G, 2Nd Floor
70210 Kuopio

UNIVERSITY OF SZEGED

Hungary

Address

Dom Ter 8
6723 Szeged