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The role of lipids in neurodegeneration and their preventive potential in diet

Objective

To prevent and treat age associated neurodegenerative diseases is a key challenge of this century. Based on recent findings it is promising to develop dietary lipid related disease prevention strategies. The present project will undertakethis strategic approach which will first be applied to Alzheimer's disease, in which brain lipids are believed to play an important role. Three converging lines of investigation will be pursued. In vitro studies of the role of lipids in neuronal degeneration and of the effects thereon of distinct lipid related treatments would be preformed first. The resulting promising treatments will than be used for the preparation of formulations whose effectiveness will be tested in vivo utilizing distinct models of neurodegeneration and dementia. The best diets will be tested in man for their ability to halt and prevent disease.

Funding Scheme

CSC - Cost-sharing contracts

Coordinator

RUPRECHT-KARLS-UNIVERSITAET HEIDELBERG
Address
Im Neuenheimer Feld 282
69120 Heidelberg
Germany

Participants (6)

INSTITUTE OF PHYSIOLOGY - CZECH ACADEMY OF SCIENCES
Czechia
Address
Videnska 1083
142 20 Praha 4
NUMICO RESEARCH B.V.
Netherlands
Address
Bosrandweg 20
6700 CA Wageningen
TEL AVIV UNIVERSITY
Israel
Address
Ramat-aviv
69978 Ramat - Aviv
UNIVERSITY OF GENEVA
Switzerland
Address
Rue Micherl Servet 1
1211 Geneve
UNIVERSITY OF KUOPIO
Finland
Address
9,Savilahdentie 9 G, 2Nd Floor
70210 Kuopio
UNIVERSITY OF SZEGED
Hungary
Address
Dom Ter 8
6723 Szeged