To prevent and treat age associated neurodegenerative diseases is a key challenge of this century. Based on recent findings it is promising to develop dietary lipid related disease prevention strategies. The present project will undertakethis strategic approach which will first be applied to Alzheimer's disease, in which brain lipids are believed to play an important role. Three converging lines of investigation will be pursued. In vitro studies of the role of lipids in neuronal degeneration and of the effects thereon of distinct lipid related treatments would be preformed first. The resulting promising treatments will than be used for the preparation of formulations whose effectiveness will be tested in vivo utilizing distinct models of neurodegeneration and dementia. The best diets will be tested in man for their ability to halt and prevent disease.
Funding SchemeCSC - Cost-sharing contracts
142 20 Praha 4
6700 CA Wageningen
69978 Ramat - Aviv