Recently, much attention is paid to the health-promoting properties of Lactobacilli and Bifid bacteria. Prebiotics and probiotics are the driving forces of the functional foods market. However, a major problem is that many of these health-promoting properties are still questioned. For instance, the fundamental basis of the inhibition of Gram-negative pathogenic bacteria - like the entero-virulent diarrheagenic Salmonellae, and Helicobacter pylori causing gastrointestinal disorders - by probiotic lactic acid bacteria has not been elucidated. This project will focus on the identification of the responsible compounds. In addition, the mechanism of the inhibition of Gram-negative pathogens by probiotic Lactobacilli and Bifid bacteria will be studied using co culture models (simulated gut fermentations, human cell lines and animal models). Clinical studies will be performed too.
Funding SchemeCSC - Cost-sharing contracts