Molecular analysis and mechanistic elucidation of the functionality of probiotics and prebiotics in the inhibition of pathogenic microorganisms to combat gastrointestinal disorders and to improve human health

Cel

Recently, much attention is paid to the health-promoting properties of Lactobacilli and Bifid bacteria. Prebiotics and probiotics are the driving forces of the functional foods market. However, a major problem is that many of these health-promoting properties are still questioned. For instance, the fundamental basis of the inhibition of Gram-negative pathogenic bacteria - like the entero-virulent diarrheagenic Salmonellae, and Helicobacter pylori causing gastrointestinal disorders - by probiotic lactic acid bacteria has not been elucidated. This project will focus on the identification of the responsible compounds. In addition, the mechanism of the inhibition of Gram-negative pathogens by probiotic Lactobacilli and Bifid bacteria will be studied using co culture models (simulated gut fermentations, human cell lines and animal models). Clinical studies will be performed too.

Dziedzina nauki

• nauki przyrodnicze › nauki chemiczne › chemia organiczna › kwasy organiczne
• nauki przyrodnicze › nauki biologiczne › mikrobiologia › bakteriologia
• inżynieria i technologia › biotechnologia przemysłowa › technologie bioprzetwarzania › fermentacja

Program(-y)

• FP5-LIFE QUALITY - Specific Programme for research, technological development and demonstration on "Quality of life and management of living resources", 1998-2002

Temat(-y)

• 1.1.1.-1. - Key action Food, Nutrition and Health

Zaproszenie do składania wniosków

Data not available

System finansowania

CSC - Cost-sharing contracts

Koordynator

VRIJE UNIVERSITEIT BRUSSEL

Adres

2,bd De La Plaine 2
1050 Bruxelles
Belgia

Uczestnicy (6)

AGRICULTURAL UNIVERSITY OF ATHENS

Grecja

Adres

Iera Odos 75
11855 Athens

AGRICULTURAL UNIVERSITY OF NORWAY

Norwegia

Adres

Meieribygningen
1432 Aas

BELDEM S.A.

Belgia

Adres

Rue Bourrie 12
5300 Andenne,seilles

DEXTER COM S.R.L.

Rumunia

Adres

Popa Rusu N°6 Ap 6
7022 Bucharest

HELLENIC PASTEUR INSTITUTE

Grecja

INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE

Francja

Adres

Rue De Tolbiac, 101
75654 Paris