Objective
Gastrointestinal nematodes are a considerable parasitic burden to the livestock industry in the EU. The associated nematodoses are currently controlled by the strategic use of anthelmintic drugs, but this has become unsustainable due to the emergence of anthelmintic resistance and increasing concerns about drug residues entering the food chain and the environment. Novel control strategies are urgently required and vaccination is now a feasible alternative. The proposed collaborative grouping has identified a number of helminth proteases which have potential as vaccine antigens. The aim of the proposed research is, initially, to assess the utility of selected native secreted and somatic proteases to protect against infection with homologous and heterologous nematode species. Subsequently, cDNAs encoding protective proteases will be isolated and expressed in recombinant form for evaluation of their vaccine utility. This work will be underpinned by a definition of the protective properties of the respective antigens and the host's immune response to vaccination. The ultimate aim is the development of monovalent/multivalent nematode vaccines.
Fields of science (EuroSciVoc)
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
- medical and health sciences basic medicine immunology
- medical and health sciences basic medicine pharmacology and pharmacy pharmaceutical drugs vaccines
- agricultural sciences animal and dairy science domestic animals animal husbandry
You need to log in or register to use this function
Programme(s)
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Topic(s)
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Call for proposal
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
Data not available
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
Funding Scheme
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Coordinator
EH26 0PZ PENICUIK
United Kingdom
The total costs incurred by this organisation to participate in the project, including direct and indirect costs. This amount is a subset of the overall project budget.