Development of novel vaccines to control infections wlth newly emerging highly pathogenic marek's disease viruses

Objective

Novel concepts to control newly emerging and highly pathogenic Marek's disease virus (vv+ MDV-1) are needed. Different antigen formulations, routes of vaccination, and biological adjuvant will be tested. DNA vaccines encoding MDV-1 antigens expressed in all stages of the virus' life cycle (lytic, latent, tumour stage) will be constructed, with an emphasis on antigens inducing a cytotoxic T cell response. The same proteins will also be expressed by recombinant Sindbis viruses. Modified live vaccines derived from a vv+ MDV-1 strain with a deletion in gB or gM shall be constructed using the bacterial artificial chromosome technique. The routes of vaccination will be
1) in-ovo vaccination and
2) vaccination of 1- day-old chickens via various routes. The cytokine profiles after MDV-1 infection will be analysed by developing new tools and test systems, and rational approaches to immune modulation using biological adjuvant will be developed and tested.

Fields of science

• natural sciences › biological sciences › microbiology › virology
• natural sciences › biological sciences › genetics › DNA
• natural sciences › biological sciences › biochemistry › biomolecules › proteins
• medical and health sciences › basic medicine › pharmacology and pharmacy › pharmaceutical drugs › vaccines
• natural sciences › biological sciences › genetics › chromosomes

Programme(s)

• FP5-LIFE QUALITY - Specific Programme for research, technological development and demonstration on "Quality of life and management of living resources", 1998-2002

Topic(s)

• 1.1.1.-2. - Key action Control of Infectious Diseases

Call for proposal

Data not available

Funding Scheme

CSC - Cost-sharing contracts

Coordinator

FRIEDRICH-LOEFLER INSTITUTE FEDERAL RESEARCH INSTITUT FOR ANIMAL HEALTH

Address

Boddenblick 5 A
17498 Insel Riems
Germany

Participants (7)

BIOLOGICAL RESEARCH CENTRE - HUNGARIAN ACADEMY OF SCIENCES

Hungary

Address

62,temesvari Krt. 62
6701 Szeged

INSTITUT NATIONAL DE LA RECHERCHE AGRONOMIQUE

France

Address

Centre De Recherche De Tours
37380 Monnaie , Nouzilly

INSTITUTE OF VIROLOGY - SLOVAK ACADEMY OF SCIENCES

Slovakia

Address

Dubravska Cesta 9
84246 Bratislava

Institute for Animal Health

United Kingdom

Address

Compton Laboratory Compton
RG16 0NN Newbury

KIMRON VETERINARY INSTITUTE

Israel

Address

Agricultural Center
50250 Bet Dagan

LOHMANN ANIMAL HEALTH GMBH & CO. KG

Germany

Address

Heinz-lohmann-strasse 4
27472 Cuxhaven

LUDWIG-MAXIMILIANS UNIVERSITY OF MUNICH

Germany

Address

Geschwister-scholl-platz 1
80539 Muenchen