CORDIS - Forschungsergebnisse der EU
CORDIS

Development of novel vaccines to control infections wlth newly emerging highly pathogenic marek's disease viruses

Ziel

Novel concepts to control newly emerging and highly pathogenic Marek's disease virus (vv+ MDV-1) are needed. Different antigen formulations, routes of vaccination, and biological adjuvant will be tested. DNA vaccines encoding MDV-1 antigens expressed in all stages of the virus' life cycle (lytic, latent, tumour stage) will be constructed, with an emphasis on antigens inducing a cytotoxic T cell response. The same proteins will also be expressed by recombinant Sindbis viruses. Modified live vaccines derived from a vv+ MDV-1 strain with a deletion in gB or gM shall be constructed using the bacterial artificial chromosome technique. The routes of vaccination will be
1) in-ovo vaccination and
2) vaccination of 1- day-old chickens via various routes. The cytokine profiles after MDV-1 infection will be analysed by developing new tools and test systems, and rational approaches to immune modulation using biological adjuvant will be developed and tested.

Aufforderung zur Vorschlagseinreichung

Data not available

Koordinator

FRIEDRICH-LOEFLER INSTITUTE FEDERAL RESEARCH INSTITUT FOR ANIMAL HEALTH
EU-Beitrag
Keine Daten
Adresse
Boddenblick 5 A
17498 INSEL RIEMS
Deutschland

Auf der Karte ansehen

Gesamtkosten
Keine Daten

Beteiligte (7)