Development of a new in vitro test for drugs and vaccine design against plus-stranded rna viruses containig ires elements

Objective

The goal of this work is to optimise an in vitro system:
i) for testing anti-viral compounds that exclusively reduce translation from viral IRES containing mRNAs and;
ii) for rational design of mutations reducing efficiency of viral translation for the development of attenuated vaccine.

Fields of science

• medical and health sciences › health sciences › infectious diseases › RNA viruses
• natural sciences › biological sciences › microbiology › virology
• medical and health sciences › basic medicine › pharmacology and pharmacy › pharmaceutical drugs › vaccines
• natural sciences › biological sciences › genetics › mutation
• natural sciences › biological sciences › genetics › RNA

Programme(s)

• FP5-LIFE QUALITY - Specific Programme for research, technological development and demonstration on "Quality of life and management of living resources", 1998-2002

Topic(s)

• 1.1.1.-2. - Key action Control of Infectious Diseases

Call for proposal

Data not available

Funding Scheme

RGI - Research grants (individual fellowships)

Coordinator

EUROPEAN MOLECULAR BIOLOGY LABORATORY

Address

Meyerhofstrasse 1
Heidelberg
Germany