Objective
Drugs against malaria are urgently needed. The morbidity and mortality inflicted by tropical malaria is associated with the adhesive properties of erythrocytes infected with the malarial parasite Plasmodium falciparum. Sequestration of infected erythrocytes severely compromises the host, resulting in damage to vital organs including the brain. The objective of this research proposal is to develop the technological and scientific base that will permit the rational design ofanti-adhesive drugs for the treatment of severe malaria. This includes a strong research initiative to
I) dissect the mechanism of differential vary gene expression;
ii) better define the receptor-legend interactions involved in adhesion;
iii) investigate post-adhesive events that lead to pathogenesis; and iv)develop an adhesion-disruptive receptor-mimicking carbohydrate. This consortium brings together the leading European scientists in these research areas .
Fields of science
Call for proposal
Data not availableFunding Scheme
CSC - Cost-sharing contracts
Coordinator
69120 Heidelberg
Germany
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Participants (6)
82152 Planegg / Krailling
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75724 Paris
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171 77 Stockholm
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Liverpool
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69120 Heidelberg
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13284 Marseille
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