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Adhesive interactions in malaria: new targets for intervention

Objective

Drugs against malaria are urgently needed. The morbidity and mortality inflicted by tropical malaria is associated with the adhesive properties of erythrocytes infected with the malarial parasite Plasmodium falciparum. Sequestration of infected erythrocytes severely compromises the host, resulting in damage to vital organs including the brain. The objective of this research proposal is to develop the technological and scientific base that will permit the rational design ofanti-adhesive drugs for the treatment of severe malaria. This includes a strong research initiative to
I) dissect the mechanism of differential vary gene expression;
ii) better define the receptor-legend interactions involved in adhesion;
iii) investigate post-adhesive events that lead to pathogenesis; and iv)develop an adhesion-disruptive receptor-mimicking carbohydrate. This consortium brings together the leading European scientists in these research areas .

Funding Scheme

CSC - Cost-sharing contracts
Leaflet | Map data © OpenStreetMap contributors, Credit: EC-GISCO, © EuroGeographics for the administrative boundaries

Coordinator

UNIVERSITAETSKLINIKUM HEIDELBERG
Address
Im Neuenheimer Feld 324
69120 Heidelberg
Germany

Participants (6)

4SC AG
Germany
Address
Am Klopferspitz 19
82152 Planegg / Krailling
INSTITUT PASTEUR
France
Address
Rue Du Docteur Roux 25
75724 Paris
KAROLINSKA INSTITUTE
Sweden
Address
13,Doktorsringen
171 77 Stockholm
LIVERPOOL SCHOOL OF TROPICAL MEDICINE
United Kingdom
Address
Pembroke Place
Liverpool
RUPRECHT-KARLS-UNIVERSITAET HEIDELBERG
Germany
Address
Im Neuenheimer Feld 282
69120 Heidelberg
UNIVERSITE DE LA MEDITERRANEE D'AIX-MARSEILLE II
France
Address
Bld Charles Livon 58 Jardin Du Pharo
13284 Marseille