Objective
New drugs that predominantly target amino acids in the HIV-1 RT pocket that cannot mutate without seriously compromising RT function will be developed. Subunitdimerisation of HIV-1 RT p66/p51 will be explored as a new tool for drug development. Also a recently discovered new micro target on RT will be investigated for development of drugs that lack cross-resistance to Notes and Norris . We will develop modalities to control endogenous dent pool ratios to attenuate the resistance spectrum of Nets and Knurls . Finally, we will develop a small animal model based on cats that are infectable by an FIV clone in which the RT has been made sensitive to the HIV-1-specific Norris, to fill the existing preclinical gap between HIV resistance research in cell culture and in the clinical setting.
Fields of science (EuroSciVoc)
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
- medical and health sciences basic medicine pharmacology and pharmacy drug discovery
- medical and health sciences health sciences infectious diseases RNA viruses HIV
- medical and health sciences basic medicine pharmacology and pharmacy drug resistance
- natural sciences chemical sciences organic chemistry amines
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Programme(s)
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Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Topic(s)
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Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
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Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
Funding Scheme
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Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Coordinator
3000 LOUVAIN / LEUVEN
Belgium
The total costs incurred by this organisation to participate in the project, including direct and indirect costs. This amount is a subset of the overall project budget.