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New tools to investigate and suppress hiv drug resistance

Objective

New drugs that predominantly target amino acids in the HIV-1 RT pocket that cannot mutate without seriously compromising RT function will be developed. Subunitdimerisation of HIV-1 RT p66/p51 will be explored as a new tool for drug development. Also a recently discovered new micro target on RT will be investigated for development of drugs that lack cross-resistance to Notes and Norris . We will develop modalities to control endogenous dent pool ratios to attenuate the resistance spectrum of Nets and Knurls . Finally, we will develop a small animal model based on cats that are infectable by an FIV clone in which the RT has been made sensitive to the HIV-1-specific Norris, to fill the existing preclinical gap between HIV resistance research in cell culture and in the clinical setting.

Funding Scheme

CSC - Cost-sharing contracts

Coordinator

KATHOLIEKE UNIVERSITEIT LEUVEN
Address
10,Minderbroedersstraat 10
3000 Louvain / Leuven
Belgium

Participants (6)

CONSEJO SUPERIOR DE INVESTIGACIONES CIENTIFICAS
Spain
Address
3,Juan De La Cierva 3
28006 Madrid
KAROLINSKA INSTITUTE
Sweden
Address
Solnavagen 1
171 77 Stockholm
THE CHANCELLOR, MASTERS AND SCHOLARS OF THE UNIVERSITY OF OXFORD
United Kingdom
Address
University Offices, Wellington Square
Oxford
UNIVERSITY OF ALCALA
Spain
Address
S/n,plaza De San Diego S/n (Colegio De San Idelfonso)
28801 Alcala De Henares
UNIVERSITÀ DEGLI STUDI DI ROMA TOR VERGATA
Italy
Address
Via Di Tor Vergata 135
00133 Roma
UTRECHT UNIVERSITY
Netherlands
Address
Yalelaan 1
3584 CL Utrecht