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Content archived on 2024-05-27

Immunological mechanisms of t cell activation by dendritic cells: a novel strategy for immune intervention

Objective

The use of dendrite cells (DC) as natural adjuvant has been proposed. Aim of this project is the delivery of new therapeutic treatments of human papillomavirus (HPV) injection. The proposed strategy torn immune cell therapy is based on the use of dendrite cells (DC), which are known to be the most powerful professional antigen presenting cells of the immune system, able to prime and activate antigen-specific immune responses. The most relevant objectives are:
1) the generation of vectors for appropriable delivery of viral antigens to DC;
2) the generation of modified DC;
3) the evaluation of safety and efficacy of modified DC therapy in pre-clinical model of virally-inducedtumors;
4) Pilot clinical trial of HPV patients with antilogous DC loaded with HPV antigens. This project aims to generate a novel therapeutically strategy which requires a broad interdisciplinary approach. The proposed DC-based therapy demands the generation and validation of new therapeutic tools. One SME will contribute to the pre-clinical studies in order to be in a favourable position to exploit the results of the project.

Fields of science (EuroSciVoc)

CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.

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Topic(s)

Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.

Call for proposal

Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.

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Funding Scheme

Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.

CSC - Cost-sharing contracts

Coordinator

UNIVERSITÀ DEGLI STUDI DI MILANO-BICOCCA
EU contribution
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Address
Piazza della Scienza 2
20126 MILANO
Italy

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Total cost

The total costs incurred by this organisation to participate in the project, including direct and indirect costs. This amount is a subset of the overall project budget.

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Participants (6)

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