Objective
Many infectious agents persist in the patient because of an insufficient immune response. Natural viral cupids are highly immunogenic but often they do not induce neutralising antibodies or a CTL response. Using genetic methods protective and T cell epitomes can be introduced into cased proteins and expressed in bacteria or yeast. It is planned to encapsulate in vitro into such chimericcapsids genes encoding cytokines which favour The and subsequent CTL responses. Recognition of such cupids by B cells would lead to efficient antibody production and The cell epitome presentation in a favourable cytokine milieu. The suitability such hepatitis B and polymer virus cased vectors shall be tested in cell cultures, in a mouse model and for chimerical hepatitis B core particles in human patients.
Fields of science (EuroSciVoc)
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques.
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques.
- medical and health sciencesmedical biotechnologygenetic engineeringgene therapy
- natural sciencesbiological sciencesmicrobiologybacteriology
- natural sciencesbiological sciencesmicrobiologyvirology
- medical and health scienceshealth sciencesinfectious diseases
- medical and health sciencesbasic medicineimmunology
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Call for proposal
Data not availableFunding Scheme
CSC - Cost-sharing contractsCoordinator
35392 GIESSEN
Germany