Objective
HVC is a growing European medical problem here there is no effective long-term therapy. Mostly fatal, this infectious disease may be chronically carried by 5 million Europeans placing a huge burden on medical services and resources. Novel and effective antiviral therapies are therefore urgently needed. We use rational drug design to develop new drugs to combat HCV at a critical stage in its life cycle. Our dugs fit a specific target in the RNA structure, freezing its shape, it is no longer able to bind its native protein, and thus viral replication is inhibited. We will determine the 3D structure of the RNA target, design and make novel drugs, develop assays to measure inhibition of RNA function, and make through iterative cycles lead molecules. In collaboration withal pharmaceutical partner such drugs would be entered into a clinical evaluation programme. This research will benefit Europeans by producing novel therapies to this debilitating and often fatal disease.
Fields of science (EuroSciVoc)
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
- medical and health sciences basic medicine medicinal chemistry
- medical and health sciences health sciences infectious diseases RNA viruses hepatitis C
- natural sciences biological sciences biochemistry biomolecules proteins
- natural sciences biological sciences genetics RNA
You need to log in or register to use this function
Programme(s)
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Topic(s)
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Call for proposal
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
Data not available
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
Funding Scheme
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Coordinator
CB1 6GB CAMBRIDGE
United Kingdom
The total costs incurred by this organisation to participate in the project, including direct and indirect costs. This amount is a subset of the overall project budget.